DSpace at KISTKIST Article2018

Full metadata record

DC Field Value Language
dc.contributor.authorHa, Min Woo-
dc.contributor.authorLee, Jun Young-
dc.contributor.authorKim, Doyoung-
dc.contributor.authorLee, Geumwoo-
dc.contributor.authorLee, Jae Kyun-
dc.contributor.authorHong, Suckchang-
dc.contributor.authorPark, Hyeung-geun-
dc.date.accessioned2024-01-19T23:33:03Z-
dc.date.available2024-01-19T23:33:03Z-
dc.date.created2021-09-03-
dc.date.issued2018-01-19-
dc.identifier.issn0022-3263-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/121801-
dc.description.abstractAn efficient synthetic method for establishing chiral alpha-thio-alpha-quaternary stereogenic center was successfully developed. The enantioselective a-alkylation of alpha-acylthiomalonates under phase-transfer catalytic conditions [50% aq. KOH, toluene, 20 degrees C, and (S,S)-3,4,5-trifluorophenyl-NAS bromide] provided the corresponding alpha-acylthio-alpha-alkylmalonates in high chemical yields (up to 99%) and high optical yields (up to 98% ee).-
dc.languageEnglish-
dc.publisherAMER CHEMICAL SOC-
dc.subjectPRACTICAL ASYMMETRIC-SYNTHESIS-
dc.subjectAMINO-
dc.subjectSULFENYLATION-
dc.subjectCONSTRUCTION-
dc.subjectARYLATION-
dc.subjectACIDS-
dc.titleEnantioselective Synthesis of Chiral alpha-Thio-Quaternary Stereogenic Centers via Phase-Transfer-Catalyzed alpha-Alkylation of alpha-Acylthiomalonates-
dc.typeArticle-
dc.identifier.doi10.1021/acs.joc.7b02605-
dc.description.journalClass1-
dc.identifier.bibliographicCitationJOURNAL OF ORGANIC CHEMISTRY, v.83, no.2, pp.1011 - 1018-
dc.citation.titleJOURNAL OF ORGANIC CHEMISTRY-
dc.citation.volume83-
dc.citation.number2-
dc.citation.startPage1011-
dc.citation.endPage1018-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000423252300045-
dc.identifier.scopusid2-s2.0-85040807884-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusPRACTICAL ASYMMETRIC-SYNTHESIS-
dc.subject.keywordPlusAMINO-
dc.subject.keywordPlusSULFENYLATION-
dc.subject.keywordPlusCONSTRUCTION-
dc.subject.keywordPlusARYLATION-
dc.subject.keywordPlusACIDS-
dc.subject.keywordAuthorbest-selling drugs-
dc.subject.keywordAuthorX-ray crystallographic structure-
dc.subject.keywordAuthorEnantioselective Synthesis-
dc.subject.keywordAuthorα-Alkylation of α-Acylthiomalonates-
Appears in Collections:
KIST Article > 2018
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML
Show Simple Item Record

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE