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A chemoselective cleavable fluorescence turn-ON linker for proteomic studies

Authors
Liew, Si Si; Du, Shubo; Ge, Jingyan; Pan, Sijun; Jang, Se-Young; Lee, Jun-Seok; Yao, Shao Q.
Issue Date
2017-12-28
Publisher
ROYAL SOC CHEMISTRY
Citation
CHEMICAL COMMUNICATIONS, v.53, no.100, pp.13332 - 13335
Abstract
We have developed a trifunctional cleavable fluorescence turn-ON linker for chemoproteomic applications. This novel linker, which became highly fluorescent only upon cleavage of the azo bond, was successfully used for in situ proteome profiling/target identification and studies on newly synthesised proteomes.
Keywords
CHEMICAL PROTEOMICS; LIVE CELLS; STREPTAVIDIN; CHEMISTRY; TARGETS; BIOLOGY; SYSTEM; PROBES; CHEMICAL PROTEOMICS; LIVE CELLS; STREPTAVIDIN; CHEMISTRY; TARGETS; BIOLOGY; SYSTEM; PROBES; chemical probe; fluorescence; chemical tag
ISSN
1359-7345
URI
https://pubs.kist.re.kr/handle/201004/121902
DOI
10.1039/c7cc08235e
Appears in Collections:
KIST Article > 2017
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