A Novel Visualization Method for Sleep Spindles Based on Source Localization of High Density EEG

Authors
Lee, SoohyunKim, SeunghwanChoi, Jee Hyun
Issue Date
2017-12
Publisher
KOREAN SOC BRAIN & NEURAL SCIENCE, KOREAN SOC NEURODEGENERATIVE DISEASE
Citation
EXPERIMENTAL NEUROBIOLOGY, v.26, no.6, pp.362 - 368
Abstract
Equivalent dipole source localization is a well-established approach to localizing the electrical activity in electroencephalogram (EEG). So far, source localization has been used primarily in localizing the epileptic source in human epileptic patients. Currently, source localization techniques have been applied to account for localizing epileptic source among the epileptic patients. Here, we present the first application of source localization in the field of sleep spindle in mouse brain. The spatial distribution of cortical potential was obtained by high density EEG and then the anterior and posterior sleep spindles were classified based on the K-mean clustering algorithm. To solve the forward problem, a realistic geometry brain model was produced based on boundary element method (BEM) using mouse MRI. Then, we applied four different source estimation algorithms (minimum norm, eLORETA, sLORETA, and LORETA) to estimate the spatial location of equivalent dipole source of sleep spindles. The estimated sources of anterior and posterior spindles were plotted in a cine-mode that revealed different topographic patterns of spindle propagation. The characterization of sleep spindles may be better be distinguished by our novel visualization method.
Keywords
ELECTROMAGNETIC TOMOGRAPHY; HIGH-RESOLUTION; BRAIN; FMRI; ELECTROMAGNETIC TOMOGRAPHY; HIGH-RESOLUTION; BRAIN; FMRI; high density EEG; mice; sleep spindles
ISSN
1226-2560
URI
https://pubs.kist.re.kr/handle/201004/121969
DOI
10.5607/en.2017.26.6.362
Appears in Collections:
KIST Article > 2017
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE