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dc.contributor.authorChin, Jungwook-
dc.contributor.authorHahn, Dongyup-
dc.contributor.authorWon, Dong Hwan-
dc.contributor.authorCho, Sung Jin-
dc.contributor.authorKim, Kyung-Hee-
dc.contributor.authorHam, Jungyeob-
dc.contributor.authorKang, Heonjoong-
dc.date.accessioned2024-01-20T01:33:15Z-
dc.date.available2024-01-20T01:33:15Z-
dc.date.created2021-09-01-
dc.date.issued2017-05-
dc.identifier.issn0253-2964-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/122799-
dc.description.abstractIn our attempt to develop a method to synthesize E- and Z-guggulsterones [antagonists of farnesoid X receptor (FXR)], we have succeeded in synthesizing E-guggulsterone selectively from three steroids, viz, 4-androsten-3, 17-dione (2), 5-androsten-3 beta-ol-17-one (DHEA) (3), and testosterone (4), in 68, 86 and 62% overall yield, respectively. We also investigated the biological effects of the synthetic E- and Z-guggulsterones and found that E-guggulsterone was more potent than Z-guggulsterone in inhibiting FXR transactivation-
dc.languageEnglish-
dc.publisher대한화학회-
dc.titleRegioselective Synthesis of the FXR Antagonist E-Guggulsterone from Three Natural Steroids-
dc.typeArticle-
dc.identifier.doi10.1002/bkcs.11120-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBulletin of the Korean Chemical Society, v.38, no.5, pp.525 - 529-
dc.citation.titleBulletin of the Korean Chemical Society-
dc.citation.volume38-
dc.citation.number5-
dc.citation.startPage525-
dc.citation.endPage529-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
dc.identifier.kciidART002223920-
dc.identifier.wosid000400992200004-
dc.identifier.scopusid2-s2.0-85017462602-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusSALT EXPORT PUMP-
dc.subject.keywordPlusX-RECEPTOR-
dc.subject.keywordPlusBILE-
dc.subject.keywordPlusSTEREOCHEMISTRY-
dc.subject.keywordPlusCHOLESTEROL-
dc.subject.keywordPlusPRODUCT-
dc.subject.keywordPlusCELLS-
dc.subject.keywordPlusACTS-
dc.subject.keywordAuthorGuggulsterone-
dc.subject.keywordAuthorNatural steroid-
dc.subject.keywordAuthorFarnesoid X receptor antagonist-
dc.subject.keywordAuthorLipid disorders-
dc.subject.keywordAuthorRegioselective synthesis-
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