Facile preparation of antibacterial polymer coatings via thiol-yne click photopolymerization

Abstract

Novel antibacterial polymer coatings were prepared by a facile thiol-yne click photopolymerization of 1-propargyl-3-alkyl-1,3-diazanyl-2,4-cyclopentadiene bromide ([PAIM]Br) and tetra(3-mercapto-propionate)pentaerythritol (PETMP) (2:1 molar ratio) using 2,2-dimethoxy-2-phenylacetophenone (DMPA) as initiator. The antibacterial activity of the coatings was tested against Staphylococcus aureus (ATCC 292130) and Escherichia coli (ATCC 25922) by the dynamic shake method. The evaluation results revealed the antibacterial polymer coatings exhibited excellent inhibitory activity against S. aureus and E. coli, especially for S. aureus. (C) 2016 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.