Synergistic effect of anti-platelet and anti-inflammation of drug-coated Co-Cr substrates for prevention of initial in-stent restenosis

Authors
Lih, EugeneJung, Jee WonJoung, Yoon KiAhn, Dong JuneHan, Dong Keun
Issue Date
2016-04-01
Publisher
ELSEVIER SCIENCE BV
Citation
COLLOIDS AND SURFACES B-BIOINTERFACES, v.140, pp.353 - 360
Abstract
Antiplatelet and antithrombotic therapies are systematically considered to prevent restenosis following coronary stent implantation. Currently, patients receiving medicated stents are prescribed to orally take anticoagulants and antiplatelet drugs such as aspirin (ASP) and prasugrel (PRAS). Propolis (PROP) known as a natural organic compound was recently evaluated for its antiplatelet activity, antibiotics and immunomodulatory activities. In this study, antiplatelet drug-coated Co-Cr substrates were prepared with biodegradable poly(D,L-lactide) (PDLLA) containing ASP, PRA, or PROP using electrospray and the blood compatibility of the different substrates was investigated by measuring protein adsorption and platelet adhesion. In addition, the anti-inflammatory properties of the modified Co-Cr surfaces were assessed by measuring IL-8 and lL-6 expression levels in human endothelial cell cultures. Drug-coated surfaces were found to resist the adsorption of fibrinogen when compared to bare Co-Cr or PDLLA-coated Co-Cr. Interestingly, ASP- and PROP-containing substrates not only showed reduced adhesion of platelets and delayed coagulation time, but also drastically reduced the expression level of IL-8 and IL-6. Such results are supported that ASP- or PROP-coated Co-Cr can be potentially used as a stent material to mitigate early stage of restenosis. The developed coating materials might be an interesting alternative to systemic anticoagulant therapies prescribed after stent implantation. (C) 2016 Elsevier B.V. All rights reserved.
Keywords
ACID PHENETHYL ESTER; SURFACE MODIFICATION; ALLOY SURFACES; ACTIVATION; ASPIRIN; ENDOTHELIALIZATION; AGGREGATION; ADSORPTION; PRASUGREL; PROPOLIS; ACID PHENETHYL ESTER; SURFACE MODIFICATION; ALLOY SURFACES; ACTIVATION; ASPIRIN; ENDOTHELIALIZATION; AGGREGATION; ADSORPTION; PRASUGREL; PROPOLIS; Drug-eluting stent (DES); Surface coating; Antiplatelet drug; Blood compatibility; Anti-inflammation
ISSN
0927-7765
URI
https://pubs.kist.re.kr/handle/201004/124188
DOI
10.1016/j.colsurfb.2016.01.009
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KIST Article > 2016
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