Therapeutic Ultrasound Contrast Agents for the Enhancement of Tumor Diagnosis and Tumor Therapy
- Authors
- Moon, Hyungwon; Yoon, Changhan; Lee, Tae Woong; Ha, Kyoung-Su; Chang, Jin Ho; Song, Tai-Kyong; Kim, Kwangmeyung; Kim, Hyuncheol
- Issue Date
- 2015-07
- Publisher
- AMER SCIENTIFIC PUBLISHERS
- Citation
- JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, v.11, no.7, pp.1183 - 1192
- Abstract
- The functionality of ultrasound in early cancer detection is limited because of its relatively low contrast resolution. Because it has a high degree of echogenicity, a microbubble contrast agent is often used to overcome this intrinsic limitation of imaging at low-contrast resolution. A targeted and drug-loaded microbubble contrast agent for simultaneous diagnosis and therapy has recently been investigated. However, no optimized theragnosis ultrasound microbubbles have been developed. Paclitaxel (PTX)-encapsulating human serum albumin nanoparticles (PTX-HSA-NPs) were conjugated onto an ultrasound microbubbles (PTX-HSA-NPs-MBs) fabricated in the laboratory to result in a narrow size distribution (1.7 +/- 0.7 mu m) and an optimal resonance frequency of 3 MHz. After intravenous injection of HSA-NPs-MBs, echogenicity in the tumor xenografted with breast cancer MCF-7 cells was significantly enhanced, showing the possibility of early cancer diagnosis. Mice injected with PTX-HSA-NPs-MBs showed higher survival rates in comparison with control groups, demonstrating the possibility of theragnosis. In the present study, the conjugation of PTX-HSA-NPs onto the ultrasound microbubbles simultaneously provided (1) enhanced ultrasound signal generation, (2) sufficient drug-loading capacity, (3) ability to deliver drugs to a preferred tumor site, and (4) increased stability in blood circulation.
- Keywords
- SERUM-ALBUMIN NANOPARTICLES; TARGETED DELIVERY; MICROBUBBLES; PACLITAXEL; TRANSFERRIN; DOXORUBICIN; CAVITATION; MECHANISM; BINDING; SURFACE; Ultrasound Contrast Agent; Microbubble; Theragnosis; Ultrasound Imaging; Drug Delivery; Tumor; Human Serum Albumin
- ISSN
- 1550-7033
- URI
- https://pubs.kist.re.kr/handle/201004/125250
- DOI
- 10.1166/jbn.2015.2056
- Appears in Collections:
- KIST Article > 2015
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