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dc.contributor.authorLee, Dahae-
dc.contributor.authorKim, Ki Hyun-
dc.contributor.authorMoon, Sung Won-
dc.contributor.authorLee, Heesu-
dc.contributor.authorKang, Ki Sung-
dc.contributor.authorLee, Jae Wook-
dc.date.accessioned2024-01-20T07:03:11Z-
dc.date.available2024-01-20T07:03:11Z-
dc.date.created2021-09-05-
dc.date.issued2015-05-01-
dc.identifier.issn0960-894X-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/125462-
dc.description.abstractChalcone analogues were prepared and evaluated for any renoprotective effects on cisplatin-treated cultured kidney cells (LLC-PK1); two chalcone analogues exhibited a potent renoprotective effect. In an additional study, we demonstrated that the blocking of MAPKs-p53-caspase-3 signaling cascade plays an important role in mediating the protective effect of these compounds against oxidative cytotoxicity in cultured LLC-PK1 cells. (C) 2015 Published by Elsevier Ltd.-
dc.languageEnglish-
dc.publisherPergamon Press Ltd.-
dc.subjectINDUCED APOPTOSIS-
dc.subjectANTICANCER-
dc.subjectINJURY-
dc.subjectINVOLVEMENT-
dc.subjectDERIVATIVES-
dc.subjectPATHWAYS-
dc.subjectGINSENG-
dc.subjectDAMAGE-
dc.subjectALPHA-
dc.titleSynthesis and biological evaluation of chalcone analogues as protective agents against cisplatin-induced cytotoxicity in kidney cells-
dc.typeArticle-
dc.identifier.doi10.1016/j.bmcl.2015.03.026-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBioorganic & Medicinal Chemistry Letters, v.25, no.9, pp.1929 - 1932-
dc.citation.titleBioorganic & Medicinal Chemistry Letters-
dc.citation.volume25-
dc.citation.number9-
dc.citation.startPage1929-
dc.citation.endPage1932-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000353205000022-
dc.identifier.scopusid2-s2.0-84933497715-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusINDUCED APOPTOSIS-
dc.subject.keywordPlusANTICANCER-
dc.subject.keywordPlusINJURY-
dc.subject.keywordPlusINVOLVEMENT-
dc.subject.keywordPlusDERIVATIVES-
dc.subject.keywordPlusPATHWAYS-
dc.subject.keywordPlusGINSENG-
dc.subject.keywordPlusDAMAGE-
dc.subject.keywordPlusALPHA-
dc.subject.keywordAuthorChalcone-
dc.subject.keywordAuthorCisplatin-induced nephrotoxicity-
dc.subject.keywordAuthorRenoprotection-
dc.subject.keywordAuthorMAPKs-p53-caspase-3-
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