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dc.contributor.authorJang, Hyuk Jai-
dc.contributor.authorJeong, Eui Kyun-
dc.contributor.authorKim, Seong Su-
dc.contributor.authorLee, Ji Hwan-
dc.contributor.authorOh, Mi Young-
dc.contributor.authorKang, Ki Sung-
dc.contributor.authorKwan, Hak Cheol-
dc.contributor.authorSong, Kyung Il-
dc.contributor.authorEom, Dae Woon-
dc.contributor.authorHan, Duck Jong-
dc.date.accessioned2024-01-20T07:30:35Z-
dc.date.available2024-01-20T07:30:35Z-
dc.date.created2022-01-25-
dc.date.issued2015-04-
dc.identifier.issn1304-0855-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/125574-
dc.description.abstractObjectives: An extract of Artemisia asiatica was reported to possess antioxidative and cytoprotective actions in various experiments. lschemia-reperfusion injury remains a major problem in kidney transplant, and the inflammatory response to ischemia-reperfusion injury exacerbates the resultant renal injury. In the present study, we investigated whether an extract of Artemisia asiatica exhibits renoprotective effects against ischemia-reperfusion-induced acute kidney injury in mice. Materials and Methods: Renal ischemia-reperfusion injury was induced in male C57BL/6 mice by bilateral renal pedicle occlusion for 30 minutes followed by reperfusion for 48 hours. An extract of Artemisia asiatica (100 mg/kg oral) was administered 4 days before ischemia-reperfusion injury. Sham operation and phosphate-buffered saline were used as controls. Blood and renal tissues were evaluated at 48 hours after ischemia-reperfusion injury. Results: Treatment with an extract of Artemisia asiatica significantly decreased blood urea nitrogen, serum creatinine levels, and kidney tubular injury (P <= .05). Western blot showed that an extract of Artemisia asiatica significantly increased the level of heme oxygenase-1 and B-cell lymphoma 2 at 48 hours after ischemia-reperfusion injury and attenuated the level of inducible nitric oxide synthase. Conclusions: An extract of Artemisia asiatica improves acute renal ischemia-reperfusion injury by reducing inflammation and apoptosis. These findings suggest that an extract of Artemisia asiatica is a potential therapeutic agent against acute ischemia-induced renal damage.-
dc.languageEnglish-
dc.publisherBASKENT UNIV-
dc.subjectAPOPTOSIS-
dc.subjectFAILURE-
dc.subjectINFLAMMATION-
dc.subjectKIDNEY-
dc.subjectRATS-
dc.subjectINHIBITION-
dc.subjectINDUCTION-
dc.subjectNECROSIS-
dc.subjectDA-9601-
dc.titleProtective Effect of Artemisia Asiatica Extract Against Renal Ischemia-Reperfusion Injury in Mice-
dc.typeArticle-
dc.identifier.doi10.6002/ect.mesot2014.P227-
dc.description.journalClass1-
dc.identifier.bibliographicCitationEXPERIMENTAL AND CLINICAL TRANSPLANTATION, v.13, pp.377 - 382-
dc.citation.titleEXPERIMENTAL AND CLINICAL TRANSPLANTATION-
dc.citation.volume13-
dc.citation.startPage377-
dc.citation.endPage382-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000355058400078-
dc.identifier.scopusid2-s2.0-84939810588-
dc.relation.journalWebOfScienceCategoryTransplantation-
dc.relation.journalResearchAreaTransplantation-
dc.type.docTypeArticle; Proceedings Paper-
dc.subject.keywordPlusAPOPTOSIS-
dc.subject.keywordPlusFAILURE-
dc.subject.keywordPlusINFLAMMATION-
dc.subject.keywordPlusKIDNEY-
dc.subject.keywordPlusRATS-
dc.subject.keywordPlusINHIBITION-
dc.subject.keywordPlusINDUCTION-
dc.subject.keywordPlusNECROSIS-
dc.subject.keywordPlusDA-9601-
dc.subject.keywordAuthorHeme oxygenase-1-
dc.subject.keywordAuthorInducible nitric oxide synthase-
dc.subject.keywordAuthorKidney transplant-
dc.subject.keywordAuthorRenal failure-
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