Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Jang, Hyuk Jai | - |
dc.contributor.author | Jeong, Eui Kyun | - |
dc.contributor.author | Kim, Seong Su | - |
dc.contributor.author | Lee, Ji Hwan | - |
dc.contributor.author | Oh, Mi Young | - |
dc.contributor.author | Kang, Ki Sung | - |
dc.contributor.author | Kwan, Hak Cheol | - |
dc.contributor.author | Song, Kyung Il | - |
dc.contributor.author | Eom, Dae Woon | - |
dc.contributor.author | Han, Duck Jong | - |
dc.date.accessioned | 2024-01-20T07:30:35Z | - |
dc.date.available | 2024-01-20T07:30:35Z | - |
dc.date.created | 2022-01-25 | - |
dc.date.issued | 2015-04 | - |
dc.identifier.issn | 1304-0855 | - |
dc.identifier.uri | https://pubs.kist.re.kr/handle/201004/125574 | - |
dc.description.abstract | Objectives: An extract of Artemisia asiatica was reported to possess antioxidative and cytoprotective actions in various experiments. lschemia-reperfusion injury remains a major problem in kidney transplant, and the inflammatory response to ischemia-reperfusion injury exacerbates the resultant renal injury. In the present study, we investigated whether an extract of Artemisia asiatica exhibits renoprotective effects against ischemia-reperfusion-induced acute kidney injury in mice. Materials and Methods: Renal ischemia-reperfusion injury was induced in male C57BL/6 mice by bilateral renal pedicle occlusion for 30 minutes followed by reperfusion for 48 hours. An extract of Artemisia asiatica (100 mg/kg oral) was administered 4 days before ischemia-reperfusion injury. Sham operation and phosphate-buffered saline were used as controls. Blood and renal tissues were evaluated at 48 hours after ischemia-reperfusion injury. Results: Treatment with an extract of Artemisia asiatica significantly decreased blood urea nitrogen, serum creatinine levels, and kidney tubular injury (P <= .05). Western blot showed that an extract of Artemisia asiatica significantly increased the level of heme oxygenase-1 and B-cell lymphoma 2 at 48 hours after ischemia-reperfusion injury and attenuated the level of inducible nitric oxide synthase. Conclusions: An extract of Artemisia asiatica improves acute renal ischemia-reperfusion injury by reducing inflammation and apoptosis. These findings suggest that an extract of Artemisia asiatica is a potential therapeutic agent against acute ischemia-induced renal damage. | - |
dc.language | English | - |
dc.publisher | BASKENT UNIV | - |
dc.subject | APOPTOSIS | - |
dc.subject | FAILURE | - |
dc.subject | INFLAMMATION | - |
dc.subject | KIDNEY | - |
dc.subject | RATS | - |
dc.subject | INHIBITION | - |
dc.subject | INDUCTION | - |
dc.subject | NECROSIS | - |
dc.subject | DA-9601 | - |
dc.title | Protective Effect of Artemisia Asiatica Extract Against Renal Ischemia-Reperfusion Injury in Mice | - |
dc.type | Article | - |
dc.identifier.doi | 10.6002/ect.mesot2014.P227 | - |
dc.description.journalClass | 1 | - |
dc.identifier.bibliographicCitation | EXPERIMENTAL AND CLINICAL TRANSPLANTATION, v.13, pp.377 - 382 | - |
dc.citation.title | EXPERIMENTAL AND CLINICAL TRANSPLANTATION | - |
dc.citation.volume | 13 | - |
dc.citation.startPage | 377 | - |
dc.citation.endPage | 382 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.identifier.wosid | 000355058400078 | - |
dc.identifier.scopusid | 2-s2.0-84939810588 | - |
dc.relation.journalWebOfScienceCategory | Transplantation | - |
dc.relation.journalResearchArea | Transplantation | - |
dc.type.docType | Article; Proceedings Paper | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | FAILURE | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | KIDNEY | - |
dc.subject.keywordPlus | RATS | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | NECROSIS | - |
dc.subject.keywordPlus | DA-9601 | - |
dc.subject.keywordAuthor | Heme oxygenase-1 | - |
dc.subject.keywordAuthor | Inducible nitric oxide synthase | - |
dc.subject.keywordAuthor | Kidney transplant | - |
dc.subject.keywordAuthor | Renal failure | - |
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