The synthesis of sulforaphane analogues and their protection effect against cisplatin induced cytotoxicity in kidney cells

Abstract

A series of sulforaphane analogues were synthesized with various amines by treatment of carbon disulfide followed by Boc(2)O and DMAP. These synthesized sulforaphane analogues were tested on cisplatin treated cultured LLC-PK1 kidney cell line. Among these analogues, several compounds including SF5 show a potent effect on kidney cell protection assay at the concentration of 2.5 mu M. Further studies with compound SF5 revealed that the kidney cell protection effect was related by inhibiting the apoptosis pathway through JNK-p53-caspase apoptotic cascade. Compound SF5 may be considered as a promising candidate for the development of new kidney protection agent against drug induced acute kidney disease. (C) 2014 Elsevier Ltd. All rights reserved.