Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Kim, Seyeon | - |
dc.contributor.author | Kim, Eunae | - |
dc.contributor.author | Oh, Chang-Hyun | - |
dc.contributor.author | Yoo, Kyung Ho | - |
dc.contributor.author | Hong, Joon Hee | - |
dc.date.accessioned | 2024-01-20T08:03:36Z | - |
dc.date.available | 2024-01-20T08:03:36Z | - |
dc.date.created | 2021-09-05 | - |
dc.date.issued | 2014-12-20 | - |
dc.identifier.issn | 0253-2964 | - |
dc.identifier.uri | https://pubs.kist.re.kr/handle/201004/125980 | - |
dc.description.abstract | The first synthetic route to 5'-norcarbocyclic C-nucleoside [7-oxa-7,9-dideazadenosine (furo[3,2-d]pyrimidine) and 9-deazaadenosine (pyrrolo[3,2-d]pyrimidine)] phosphonic acids from commercially available 1,3dihydroxy cyclopentane was described. The key C-C bond formation from sugar to base precursor was performed using Knoevenagel-type condensation from a ketone derivative. Synthesized C-nucleoside phosphonic acids were tested for anti-HIV activity as well as anti-leukemic activity. Compound 26 showed significant anti-leukemic activity. | - |
dc.language | English | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.subject | ENANTIOSELECTIVE SYNTHESIS | - |
dc.subject | ANTIVIRAL ACTIVITY | - |
dc.subject | NUCLEOTIDE ANALOGS | - |
dc.subject | FACILE SYNTHESIS | - |
dc.subject | ADENOSINE | - |
dc.title | Synthesis and Potent Anti-leukemic Activity of Novel 5 '-Norcarbocyclic C-nucleoside Phosphonic Acids | - |
dc.type | Article | - |
dc.identifier.doi | 10.5012/bkcs.2014.35.12.3502 | - |
dc.description.journalClass | 1 | - |
dc.identifier.bibliographicCitation | BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.35, no.12, pp.3502 - 3508 | - |
dc.citation.title | BULLETIN OF THE KOREAN CHEMICAL SOCIETY | - |
dc.citation.volume | 35 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 3502 | - |
dc.citation.endPage | 3508 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.identifier.kciid | ART001932306 | - |
dc.identifier.wosid | 000346113000017 | - |
dc.identifier.scopusid | 2-s2.0-84920067251 | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | ENANTIOSELECTIVE SYNTHESIS | - |
dc.subject.keywordPlus | ANTIVIRAL ACTIVITY | - |
dc.subject.keywordPlus | NUCLEOTIDE ANALOGS | - |
dc.subject.keywordPlus | FACILE SYNTHESIS | - |
dc.subject.keywordPlus | ADENOSINE | - |
dc.subject.keywordAuthor | Antiviral agent | - |
dc.subject.keywordAuthor | Anti-leukemic agent | - |
dc.subject.keywordAuthor | C-nucleoside | - |
dc.subject.keywordAuthor | Knoevenagel reaction | - |
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