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dc.contributor.authorKim, Seyeon-
dc.contributor.authorKim, Eunae-
dc.contributor.authorOh, Chang-Hyun-
dc.contributor.authorYoo, Kyung Ho-
dc.contributor.authorHong, Joon Hee-
dc.date.accessioned2024-01-20T08:03:36Z-
dc.date.available2024-01-20T08:03:36Z-
dc.date.created2021-09-05-
dc.date.issued2014-12-20-
dc.identifier.issn0253-2964-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/125980-
dc.description.abstractThe first synthetic route to 5'-norcarbocyclic C-nucleoside [7-oxa-7,9-dideazadenosine (furo[3,2-d]pyrimidine) and 9-deazaadenosine (pyrrolo[3,2-d]pyrimidine)] phosphonic acids from commercially available 1,3dihydroxy cyclopentane was described. The key C-C bond formation from sugar to base precursor was performed using Knoevenagel-type condensation from a ketone derivative. Synthesized C-nucleoside phosphonic acids were tested for anti-HIV activity as well as anti-leukemic activity. Compound 26 showed significant anti-leukemic activity.-
dc.languageEnglish-
dc.publisherWILEY-V C H VERLAG GMBH-
dc.subjectENANTIOSELECTIVE SYNTHESIS-
dc.subjectANTIVIRAL ACTIVITY-
dc.subjectNUCLEOTIDE ANALOGS-
dc.subjectFACILE SYNTHESIS-
dc.subjectADENOSINE-
dc.titleSynthesis and Potent Anti-leukemic Activity of Novel 5 '-Norcarbocyclic C-nucleoside Phosphonic Acids-
dc.typeArticle-
dc.identifier.doi10.5012/bkcs.2014.35.12.3502-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.35, no.12, pp.3502 - 3508-
dc.citation.titleBULLETIN OF THE KOREAN CHEMICAL SOCIETY-
dc.citation.volume35-
dc.citation.number12-
dc.citation.startPage3502-
dc.citation.endPage3508-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
dc.identifier.kciidART001932306-
dc.identifier.wosid000346113000017-
dc.identifier.scopusid2-s2.0-84920067251-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusENANTIOSELECTIVE SYNTHESIS-
dc.subject.keywordPlusANTIVIRAL ACTIVITY-
dc.subject.keywordPlusNUCLEOTIDE ANALOGS-
dc.subject.keywordPlusFACILE SYNTHESIS-
dc.subject.keywordPlusADENOSINE-
dc.subject.keywordAuthorAntiviral agent-
dc.subject.keywordAuthorAnti-leukemic agent-
dc.subject.keywordAuthorC-nucleoside-
dc.subject.keywordAuthorKnoevenagel reaction-
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