An Animal Model of Obstructive Sleep Apnea in Rabbit

Authors
Yu, Myeong S.Jung, Na R.Choi, Kyoung H.Choi, KuiwonLee, Bong-JaeChung, Yoo-Sam
Issue Date
2014-03
Publisher
WILEY-BLACKWELL
Citation
LARYNGOSCOPE, v.124, no.3, pp.789 - 796
Abstract
Objectives/HypothesisAn animal model of obstructive sleep apnea (OSA) may help to investigate the pathophysiology of this disorder and develop appropriate treatments. We investigated the feasibility of a rabbit model of OSA. Study DesignAnimal study. MethodsTwelve New Zealand white rabbits were injected at the base of their tongues under endoscopic guidance with liquid silicone (experimental group, n=6) or normal saline (control group, n=6). Polysomnography was performed before and after injection. The development of OSA and changes in sleep parameters were compared between the two groups. ResultsBefore injection, all rabbits showed normal breathing during sleep without hypopnea. In the silicone group, the rabbits had a mean of 29.96.9 hypopneas/hour and a mean of 10.43.1 apneas/hour 1 month after silicone injection and 28.4 +/- 6.9 hypopneas/hour and 10.0 +/- 3.3 apneas/hour 3 months after silicone injection (P<0.05). Mean total sleep time decreased from 260.3 +/- 70.2 minutes at baseline to 152.5 +/- 38.8 minutes 1 month and 206.8 +/- 60.3 minutes 3 months after injection, with a decrease in stage II sleep. In the saline group, however, there were no breathing events during sleep. ConclusionsThese results show that silicone injections into the tongue base of rabbits can result in OSA. Level of EvidenceN/A Laryngoscope, 124:789-796, 2014
Keywords
PATHOGENESIS; PRESSURE; OXIMETRY; PIGS; Rabbit; animal model; obstructive sleep apnea; sleep
ISSN
0023-852X
URI
https://pubs.kist.re.kr/handle/201004/127017
DOI
10.1002/lary.24398
Appears in Collections:
KIST Article > 2014
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE