Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Thambi, Thavasyappan | - |
dc.contributor.author | Deepagan, V. G. | - |
dc.contributor.author | Yoon, Hong Yeol | - |
dc.contributor.author | Han, Hwa Seung | - |
dc.contributor.author | Kim, Seol-Hee | - |
dc.contributor.author | Son, Soyoung | - |
dc.contributor.author | Jo, Dong-Gyu | - |
dc.contributor.author | Ahn, Cheol-Hee | - |
dc.contributor.author | Suh, Yung Doug | - |
dc.contributor.author | Kim, Kwangmeyung | - |
dc.contributor.author | Kwon, Ick Chan | - |
dc.contributor.author | Lee, Doo Sung | - |
dc.contributor.author | Park, Jae Hyung | - |
dc.date.accessioned | 2024-01-20T10:32:07Z | - |
dc.date.available | 2024-01-20T10:32:07Z | - |
dc.date.created | 2021-09-05 | - |
dc.date.issued | 2014-02 | - |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.uri | https://pubs.kist.re.kr/handle/201004/127142 | - |
dc.description.abstract | Hypoxia is a condition found in various intractable diseases. Here, we report self-assembled nanoparticles which can selectively release the hydrophobic agents under hypoxic conditions. For the preparation of hypoxia-responsive nanoparticles (HR-NPs), a hydrophobically modified 2-nitroimidazole derivative was conjugated to the backbone of the carboxymethyl dextran (CM-Dex). Doxorubicin (DOX), a model drug, was effectively encapsulated into the HR-NPs. The HR-NPs released DOX in a sustained manner under the normoxic condition (physiological condition), whereas the drug release rate. remarkably increased under the hypoxic condition. From in vitro cytotoxicity tests, it was found the DOX-loaded HR-NPs showed higher toxicity to hypoxic cells than to normoxic cells. Microscopic observation showed that the HR-NPs could effectively deliver DOX into SCC7 cells under hypoxic conditions. In vivo biodistribution study demonstrated that HR-NPs were selectively accumulated at the hypoxic tumor tissues. As consequence, drug-loaded HR-NPs exhibited high anti-tumor activity in vivo. Overall, the HR-NPs might have a potential as nanocarriers for drug delivery to treat hypoxia-associated diseases. (C) 2013 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.subject | GLYCOL CHITOSAN NANOPARTICLES | - |
dc.subject | CANCER-THERAPY | - |
dc.subject | POLY(ETHYLENE GLYCOL) | - |
dc.subject | FLUORESCENT MARKERS | - |
dc.subject | BLOCK-COPOLYMERS | - |
dc.subject | CELLS | - |
dc.subject | DOXORUBICIN | - |
dc.subject | CAMPTOTHECIN | - |
dc.subject | MECHANISMS | - |
dc.subject | CONJUGATE | - |
dc.title | Hypoxia-responsive polymeric nanoparticles for tumor-targeted drug delivery | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.biomaterials.2013.11.022 | - |
dc.description.journalClass | 1 | - |
dc.identifier.bibliographicCitation | BIOMATERIALS, v.35, no.5, pp.1735 - 1743 | - |
dc.citation.title | BIOMATERIALS | - |
dc.citation.volume | 35 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1735 | - |
dc.citation.endPage | 1743 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.identifier.wosid | 000330156100038 | - |
dc.identifier.scopusid | 2-s2.0-84890175659 | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | GLYCOL CHITOSAN NANOPARTICLES | - |
dc.subject.keywordPlus | CANCER-THERAPY | - |
dc.subject.keywordPlus | POLY(ETHYLENE GLYCOL) | - |
dc.subject.keywordPlus | FLUORESCENT MARKERS | - |
dc.subject.keywordPlus | BLOCK-COPOLYMERS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | DOXORUBICIN | - |
dc.subject.keywordPlus | CAMPTOTHECIN | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | CONJUGATE | - |
dc.subject.keywordAuthor | Hypoxia | - |
dc.subject.keywordAuthor | Nanoparticles | - |
dc.subject.keywordAuthor | 2-Nitroimidazole | - |
dc.subject.keywordAuthor | Bioreduction | - |
dc.subject.keywordAuthor | Drug delivery | - |
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