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dc.contributor.authorThambi, Thavasyappan-
dc.contributor.authorDeepagan, V. G.-
dc.contributor.authorYoon, Hong Yeol-
dc.contributor.authorHan, Hwa Seung-
dc.contributor.authorKim, Seol-Hee-
dc.contributor.authorSon, Soyoung-
dc.contributor.authorJo, Dong-Gyu-
dc.contributor.authorAhn, Cheol-Hee-
dc.contributor.authorSuh, Yung Doug-
dc.contributor.authorKim, Kwangmeyung-
dc.contributor.authorKwon, Ick Chan-
dc.contributor.authorLee, Doo Sung-
dc.contributor.authorPark, Jae Hyung-
dc.date.accessioned2024-01-20T10:32:07Z-
dc.date.available2024-01-20T10:32:07Z-
dc.date.created2021-09-05-
dc.date.issued2014-02-
dc.identifier.issn0142-9612-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/127142-
dc.description.abstractHypoxia is a condition found in various intractable diseases. Here, we report self-assembled nanoparticles which can selectively release the hydrophobic agents under hypoxic conditions. For the preparation of hypoxia-responsive nanoparticles (HR-NPs), a hydrophobically modified 2-nitroimidazole derivative was conjugated to the backbone of the carboxymethyl dextran (CM-Dex). Doxorubicin (DOX), a model drug, was effectively encapsulated into the HR-NPs. The HR-NPs released DOX in a sustained manner under the normoxic condition (physiological condition), whereas the drug release rate. remarkably increased under the hypoxic condition. From in vitro cytotoxicity tests, it was found the DOX-loaded HR-NPs showed higher toxicity to hypoxic cells than to normoxic cells. Microscopic observation showed that the HR-NPs could effectively deliver DOX into SCC7 cells under hypoxic conditions. In vivo biodistribution study demonstrated that HR-NPs were selectively accumulated at the hypoxic tumor tissues. As consequence, drug-loaded HR-NPs exhibited high anti-tumor activity in vivo. Overall, the HR-NPs might have a potential as nanocarriers for drug delivery to treat hypoxia-associated diseases. (C) 2013 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherELSEVIER SCI LTD-
dc.subjectGLYCOL CHITOSAN NANOPARTICLES-
dc.subjectCANCER-THERAPY-
dc.subjectPOLY(ETHYLENE GLYCOL)-
dc.subjectFLUORESCENT MARKERS-
dc.subjectBLOCK-COPOLYMERS-
dc.subjectCELLS-
dc.subjectDOXORUBICIN-
dc.subjectCAMPTOTHECIN-
dc.subjectMECHANISMS-
dc.subjectCONJUGATE-
dc.titleHypoxia-responsive polymeric nanoparticles for tumor-targeted drug delivery-
dc.typeArticle-
dc.identifier.doi10.1016/j.biomaterials.2013.11.022-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBIOMATERIALS, v.35, no.5, pp.1735 - 1743-
dc.citation.titleBIOMATERIALS-
dc.citation.volume35-
dc.citation.number5-
dc.citation.startPage1735-
dc.citation.endPage1743-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000330156100038-
dc.identifier.scopusid2-s2.0-84890175659-
dc.relation.journalWebOfScienceCategoryEngineering, Biomedical-
dc.relation.journalWebOfScienceCategoryMaterials Science, Biomaterials-
dc.relation.journalResearchAreaEngineering-
dc.relation.journalResearchAreaMaterials Science-
dc.type.docTypeArticle-
dc.subject.keywordPlusGLYCOL CHITOSAN NANOPARTICLES-
dc.subject.keywordPlusCANCER-THERAPY-
dc.subject.keywordPlusPOLY(ETHYLENE GLYCOL)-
dc.subject.keywordPlusFLUORESCENT MARKERS-
dc.subject.keywordPlusBLOCK-COPOLYMERS-
dc.subject.keywordPlusCELLS-
dc.subject.keywordPlusDOXORUBICIN-
dc.subject.keywordPlusCAMPTOTHECIN-
dc.subject.keywordPlusMECHANISMS-
dc.subject.keywordPlusCONJUGATE-
dc.subject.keywordAuthorHypoxia-
dc.subject.keywordAuthorNanoparticles-
dc.subject.keywordAuthor2-Nitroimidazole-
dc.subject.keywordAuthorBioreduction-
dc.subject.keywordAuthorDrug delivery-
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