Mapping mammalian synaptic connectivity

Authors
Yook, ChaehyunDruckmann, ShaulKim, Jinhyun
Issue Date
2013-12
Publisher
SPRINGER BASEL AG
Citation
CELLULAR AND MOLECULAR LIFE SCIENCES, v.70, no.24, pp.4747 - 4757
Abstract
Mapping mammalian synaptic connectivity has long been an important goal of neuroscientists since it is considered crucial for explaining human perception and behavior. Yet, despite enormous efforts, the overwhelming complexity of the neural circuitry and the lack of appropriate techniques to unravel it have limited the success of efforts to map connectivity. However, recent technological advances designed to overcome the limitations of conventional methods for connectivity mapping may bring about a turning point. Here, we address the promises and pitfalls of these new mapping technologies.
Keywords
STRUCTURED-ILLUMINATION MICROSCOPY; DE-NOVO MUTATIONS; AUTISM SPECTRUM DISORDERS; CENTRAL-NERVOUS-SYSTEM; COPY NUMBER VARIATION; RABIES VIRUS; TRANSNEURONAL TRACER; BRAIN CONNECTIVITY; NEURONAL NETWORKS; PYRAMIDAL NEURONS; STRUCTURED-ILLUMINATION MICROSCOPY; DE-NOVO MUTATIONS; AUTISM SPECTRUM DISORDERS; CENTRAL-NERVOUS-SYSTEM; COPY NUMBER VARIATION; RABIES VIRUS; TRANSNEURONAL TRACER; BRAIN CONNECTIVITY; NEURONAL NETWORKS; PYRAMIDAL NEURONS; Synaptic connectivity; Brainbow; Array tomography; mGRASP; Trans-synaptic tracer; Neurological disorders
ISSN
1420-682X
URI
https://pubs.kist.re.kr/handle/201004/127392
DOI
10.1007/s00018-013-1417-y
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KIST Article > 2013
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