2-Phenylbenzofuran derivatives alleviate mitochondrial damage via the inhibition of beta-amyloid aggregation

Abstract

To obtain modulators for reducing mitochondrial damage by the inhibition of A beta oligomer formation, 2-phenylbenzofuran derivatives were designed and prepared. Their inhibitory activity against A beta fibril formation was screened using ThT fluorescence assay, and the effect of derivatives on mitochondrial function was evaluated using JC-1 and MTT assay. 2-Phenylbenzofuran derivatives with dimethylamino group at p-position had an excellent inhibitory activity against A beta fibril formation. Particularly, compound 19m alleviated mitochondrial damage remarkably and possessed protective effects against A beta-induced cytotoxicity. (C) 2013 Elsevier Ltd. All rights reserved.