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dc.contributor.authorKim, Jae Yeon-
dc.contributor.authorLee, Hwanbum-
dc.contributor.authorOh, Keun Sang-
dc.contributor.authorKweon, Seho-
dc.contributor.authorJeon, Ok-cheol-
dc.contributor.authorByun, Youngro-
dc.contributor.authorKim, Kwangmeyung-
dc.contributor.authorKwon, Ick Chan-
dc.contributor.authorKim, Sang Yoon-
dc.contributor.authorYuk, Soon Hong-
dc.date.accessioned2024-01-20T11:04:13Z-
dc.date.available2024-01-20T11:04:13Z-
dc.date.created2021-09-05-
dc.date.issued2013-11-
dc.identifier.issn0142-9612-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/127491-
dc.description.abstractA method for the sustained delivery of exenatide was proposed using nanoparticles (NPs) with a core/shell structure. The interactions between lipid bilayers and Pluronics were utilized to form various NPs using a layer-by-layer approach. Transmittance electron microscopy and dynamic light scattering were used to examine the morphology of the NPs. The in vitro release pattern was observed as a function of changes in the structure of the NPs, and the structural integrity of exenatide released was examined by SDS-PAGE analysis. Pharmacokinetics and antidiabetic effects were also observed with the structural change of NPs using in vivo animal models. In vitro-in vivo correlation was discussed in relation to manipulation of the NP structures. (C) 2013 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherELSEVIER SCI LTD-
dc.subjectDRUG-DELIVERY-
dc.subjectCORE/SHELL NANOPARTICLES-
dc.subjectLIPOSOME FUSION-
dc.subjectVESICLE FUSION-
dc.subjectEXENDIN-4-
dc.subjectCAPSULES-
dc.subjectBILAYER-
dc.subjectRECEPTOR-
dc.subjectCORE-
dc.titleMultilayer nanoparticles for sustained delivery of exenatide to treat type 2 diabetes mellitus-
dc.typeArticle-
dc.identifier.doi10.1016/j.biomaterials.2013.07.040-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBIOMATERIALS, v.34, no.33, pp.8444 - 8449-
dc.citation.titleBIOMATERIALS-
dc.citation.volume34-
dc.citation.number33-
dc.citation.startPage8444-
dc.citation.endPage8449-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000324720700044-
dc.identifier.scopusid2-s2.0-84881663280-
dc.relation.journalWebOfScienceCategoryEngineering, Biomedical-
dc.relation.journalWebOfScienceCategoryMaterials Science, Biomaterials-
dc.relation.journalResearchAreaEngineering-
dc.relation.journalResearchAreaMaterials Science-
dc.type.docTypeArticle-
dc.subject.keywordPlusDRUG-DELIVERY-
dc.subject.keywordPlusCORE/SHELL NANOPARTICLES-
dc.subject.keywordPlusLIPOSOME FUSION-
dc.subject.keywordPlusVESICLE FUSION-
dc.subject.keywordPlusEXENDIN-4-
dc.subject.keywordPlusCAPSULES-
dc.subject.keywordPlusBILAYER-
dc.subject.keywordPlusRECEPTOR-
dc.subject.keywordPlusCORE-
dc.subject.keywordAuthorCore/shell nanoparticles-
dc.subject.keywordAuthorLayer-by-layer approach-
dc.subject.keywordAuthorPluronics-
dc.subject.keywordAuthorLipid bilayers-
dc.subject.keywordAuthorSustained delivery of exenatide-
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