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dc.contributor.authorShim, Young Sun-
dc.contributor.authorHwang, Hyun Sook-
dc.contributor.authorNam, Ghilsoo-
dc.contributor.authorChoi, Kyung Il-
dc.date.accessioned2024-01-20T11:34:42Z-
dc.date.available2024-01-20T11:34:42Z-
dc.date.created2021-09-05-
dc.date.issued2013-08-20-
dc.identifier.issn0253-2964-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/127764-
dc.description.abstractThiourea and vinyl sulfoxide derivatives were designed based on the structures of sulforaphane and gallic acid, prepared and tested for HO-1 inducing activity as a measure of Nrf2 activation, and inhibitory effect on NO production as a measure of anti-inflammatory activity. Both series of compounds showed moderate activity on HO-I induction, and no inhibitory effect on NO production. Interestingly the thiourea compound 6d showed better HO-1 induction (71% SFN) than the corresponding isothiocyanate compound 6a (55% SFN). Overall, it seemed that more efficient electrophile is needed to get more effective Nrf2 activator.-
dc.languageEnglish-
dc.publisherKOREAN CHEMICAL SOC-
dc.subjectTRANSCRIPTION FACTOR NRF2-
dc.subjectPARKINSONS-DISEASE-
dc.subjectELEMENT-
dc.subjectSYSTEMS-
dc.subjectTARGET-
dc.subjectASSAY-
dc.subjectGENE-
dc.titleSynthesis and Nrf2 Activating Ability of Thiourea and Vinyl Sulfoxide Derivatives-
dc.typeArticle-
dc.identifier.doi10.5012/bkcs.2013.34.8.2317-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.34, no.8, pp.2317 - 2320-
dc.citation.titleBULLETIN OF THE KOREAN CHEMICAL SOCIETY-
dc.citation.volume34-
dc.citation.number8-
dc.citation.startPage2317-
dc.citation.endPage2320-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
dc.identifier.kciidART001793423-
dc.identifier.wosid000323854400018-
dc.identifier.scopusid2-s2.0-84884165363-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusTRANSCRIPTION FACTOR NRF2-
dc.subject.keywordPlusPARKINSONS-DISEASE-
dc.subject.keywordPlusELEMENT-
dc.subject.keywordPlusSYSTEMS-
dc.subject.keywordPlusTARGET-
dc.subject.keywordPlusASSAY-
dc.subject.keywordPlusGENE-
dc.subject.keywordAuthorThiourea-
dc.subject.keywordAuthorVinyl sulfoxide-
dc.subject.keywordAuthorNrf2 activator-
dc.subject.keywordAuthorParkinson&apos-
dc.subject.keywordAuthors disease-
dc.subject.keywordAuthorOxidative stress-
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