DSpace at KISTKIST Article2013

Full metadata record

DC Field Value Language
dc.contributor.authorKim, Hee Jin-
dc.contributor.authorOh, Chang-Hyun-
dc.contributor.authorYoo, Kyung Ho-
dc.date.accessioned2024-01-20T11:34:43Z-
dc.date.available2024-01-20T11:34:43Z-
dc.date.created2021-09-05-
dc.date.issued2013-08-20-
dc.identifier.issn0253-2964-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/127765-
dc.description.abstractA series of new diarylamide and diarylurea derivatives possessing pyrimidinylaminobenzene scaffold was synthesized. Their in vitro antiproliferative activities were tested against A375P human melanoma cell line. Among them, compounds la-c, k and 2b-d, f, g, j, 1 showed superior potencies against A375P human melanoma cell line to Sorafenib. In particular, compound 21 possessing 3-fluoro-5-trifluoromethyl moiety exhibited the highest potency with IC50 value in nanomolar scale.-
dc.languageEnglish-
dc.publisherKOREAN CHEMICAL SOC-
dc.subjectDESIGN-
dc.subjectSORAFENIB-
dc.subjectDIAGNOSIS-
dc.subjectTHERAPY-
dc.titleSynthesis of New Pyrimidinylaminobenzene Derivatives and Their Antiproliferative Activities against Melanoma Cell Line-
dc.typeArticle-
dc.identifier.doi10.5012/bkcs.2013.34.8.2311-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.34, no.8, pp.2311 - 2316-
dc.citation.titleBULLETIN OF THE KOREAN CHEMICAL SOCIETY-
dc.citation.volume34-
dc.citation.number8-
dc.citation.startPage2311-
dc.citation.endPage2316-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
dc.identifier.kciidART001793422-
dc.identifier.wosid000323854400017-
dc.identifier.scopusid2-s2.0-84884164357-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusDESIGN-
dc.subject.keywordPlusSORAFENIB-
dc.subject.keywordPlusDIAGNOSIS-
dc.subject.keywordPlusTHERAPY-
dc.subject.keywordAuthorAntiproliferative activity-
dc.subject.keywordAuthorPyrimidinylaminobenzene-
dc.subject.keywordAuthorDiarylamide-
dc.subject.keywordAuthorDiarylurea-
dc.subject.keywordAuthorMelanoma-
Appears in Collections:
KIST Article > 2013
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML
Show Simple Item Record

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE