Preparation of enhanced hydrophobic poly(L-lactide-co-epsilon-caprolactone) films surface and its blood compatibility

Authors
Kim, Seung IlLim, Jin IkJung, YoungmeeMun, Cho HayKim, Ji HeungKim, Soo Hyun
Issue Date
2013-07-01
Publisher
ELSEVIER
Citation
APPLIED SURFACE SCIENCE, v.276, pp.586 - 591
Abstract
Hydrophobicity-enhanced poly(L-lactide- co-epsilon-caprolactone) (PLCL) (50: 50) films were cast by using the solvent-nonsolvent casting method. PLCL (50: 50) was synthesized by the well-known random copolymerization process and confirmed by 1H NMR analysis. The molecular weight of the synthesized PLCL was measured by gel permeation chromatography (GPC). Number-average (Mn), weight-average (Mw) molecular weights and polydispersity (Mw/Mn) were 7 x 10(4), 1.2 x 10(5), and 1.7, respectively. PLCL films were cast in vacuum condition with various nonsolvents and nonsolvent ratios. Tetrahydrofuran (THF) was used as the solvent and three different alcohols were used as the nonsolvent: methanol, ethanol, and isopropyl alcohol (IPA). Surface hydrophobicity was confirmed by water contact angle. The water contact angle was increased from 81 degrees +/- 2. to 107 degrees +/- 2 degrees. Water contact angle was influenced by surface porosity and topography. The prepared film surfaces were characterized by scanning electron microscopy (SEM) and atomic force microscopy (AFM). The change of crystalline property was characterized by X-ray diffraction (XRD). Platelet adhesion tests on the modified PLCL film surfaces were evaluated by platelet-rich plasma (PRP). The modified film surface exhibited enhanced hydrophobicity and reduced platelet adhesion ratio depending on the surface topography. One of the candidate products proposed as a potential blood compatible material showed a markedly reduced platelet adhesion property. (C) 2013 Elsevier B.V. All rights reserved.
Keywords
SUPERHYDROPHOBIC SURFACE; LOTUS; SUPERHYDROPHOBIC SURFACE; LOTUS; PLCL; Blood compatibility; Surface modification; Porous material; Hydrophobicity
ISSN
0169-4332
URI
https://pubs.kist.re.kr/handle/201004/127881
DOI
10.1016/j.apsusc.2013.03.137
Appears in Collections:
KIST Article > 2013
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