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dc.contributor.authorKim, Young-Min-
dc.contributor.authorPark, Mi-Ran-
dc.contributor.authorSong, Soo-Chang-
dc.date.accessioned2024-01-20T12:05:02Z-
dc.date.available2024-01-20T12:05:02Z-
dc.date.created2021-09-04-
dc.date.issued2013-06-
dc.identifier.issn0142-9612-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/128023-
dc.description.abstractAn approach for application of cell penetration to selective small interference RNA (siRNA) localized delivery system, cell penetrable nano-polyplex assembled hydrogel system, is presented. The cell penetrable nano-polyplex assembled hydrogelisprepared by protamine conjugation to poly(organophosphazene) and inducement of nano-polyplexes with siRNAs. After an injection of cell penetrable nano-polyplex solution into the body, it turns into a gel due to thermosensitivity of poly(organophosphazene). The gel maintains up to 4 weeks and the released 30 nm-sized nano-polyplexes from the gel induces highly effective siRNA delivery due to cell penetration. Accordingly, the new system shows a high gene silencing efficiency on only the target site in long-term with a single injection. (C) 2013 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherELSEVIER SCI LTD-
dc.subjectRNA INTERFERENCE-
dc.titleAn injectable cell penetrable nano-polyplex hydrogel for localized siRNA delivery-
dc.typeArticle-
dc.identifier.doi10.1016/j.biomaterials.2013.02.050-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBIOMATERIALS, v.34, no.18, pp.4493 - 4500-
dc.citation.titleBIOMATERIALS-
dc.citation.volume34-
dc.citation.number18-
dc.citation.startPage4493-
dc.citation.endPage4500-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000317884800009-
dc.identifier.scopusid2-s2.0-84875607485-
dc.relation.journalWebOfScienceCategoryEngineering, Biomedical-
dc.relation.journalWebOfScienceCategoryMaterials Science, Biomaterials-
dc.relation.journalResearchAreaEngineering-
dc.relation.journalResearchAreaMaterials Science-
dc.type.docTypeArticle-
dc.subject.keywordPlusRNA INTERFERENCE-
dc.subject.keywordAuthorCell penetration-
dc.subject.keywordAuthorGene delivery-
dc.subject.keywordAuthorNano-polyplex-
dc.subject.keywordAuthorPolyplex hydrogel-
dc.subject.keywordAuthorSmall interference RNA (siRNA)-
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