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dc.contributor.authorShin, Hyo-Nim-
dc.contributor.authorSeo, Seon Hee-
dc.contributor.authorChoo, Hyunah-
dc.contributor.authorKuem, Gyochang-
dc.contributor.authorChoi, Kyung Il-
dc.contributor.authorNam, Ghilsoo-
dc.date.accessioned2024-01-20T12:34:43Z-
dc.date.available2024-01-20T12:34:43Z-
dc.date.created2021-09-01-
dc.date.issued2013-03-01-
dc.identifier.issn0960-894X-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/128259-
dc.description.abstractA novel series of 5(R)-[1,2,3]triazolylmethyl and (5R)-[(4-F-[1,2,3]triazolyl)methyl]oxazolidinones having various piperidine group were synthesized and evaluated antibacterial activity against clinically isolated resistant strains of Gram-positive and Gram-negative bacteria. The compound 12a having exo-cyanoethylidene group in the 4-position of piperidine ring was found to be two to threefold more potent than the linezolid against penicillin-resistant Staphylococcus pneumonia and Staphylococcus agalactiae, and also exhibited reduced MAO-B inhibitory activity. (C) 2013 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherPergamon Press Ltd.-
dc.subjectIN-VITRO ACTIVITY-
dc.subjectIDENTIFICATION-
dc.titleSynthesis and antibacterial activities of new piperidine substituted (5R)-[1,2,3]triazolylmethyl and (5R)-[(4-F-[1,2,3]triazolyl)methyl]oxazolidinones-
dc.typeArticle-
dc.identifier.doi10.1016/j.bmcl.2013.01.033-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBioorganic & Medicinal Chemistry Letters, v.23, no.5, pp.1193 - 1196-
dc.citation.titleBioorganic & Medicinal Chemistry Letters-
dc.citation.volume23-
dc.citation.number5-
dc.citation.startPage1193-
dc.citation.endPage1196-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000314693400006-
dc.identifier.scopusid2-s2.0-84873727335-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusIN-VITRO ACTIVITY-
dc.subject.keywordPlusIDENTIFICATION-
dc.subject.keywordAuthorOxazolidinone-
dc.subject.keywordAuthorAntibiotics-
dc.subject.keywordAuthorSynthesis-
dc.subject.keywordAuthorAntibacterial activity-
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