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dc.contributor.authorButler, Shannon M.-
dc.contributor.authorWallig, Matthew A.-
dc.contributor.authorNho, Chu Won-
dc.contributor.authorPan, Cheol-Ho-
dc.contributor.authorLee, Eun-Ha-
dc.contributor.authorJung, Sang Hoon-
dc.contributor.authorJeffery, Elizabeth H.-
dc.date.accessioned2024-01-20T13:00:28Z-
dc.date.available2024-01-20T13:00:28Z-
dc.date.created2021-09-01-
dc.date.issued2013-03-
dc.identifier.issn0278-6915-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/128293-
dc.description.abstractGymnaster koraiensis (GK) is a Korean herb used in folk medicine and recently found to positively impact liver health. Because GK contains polyacetylenes and because other polyacetylenes have been found to exhibit anti-inflammatory and anti-cancer activities, we hypothesized that the polyacetylene gymnasterkoreayne B (GKB), known to increase hepatic detoxification enzymes, may also exert anti-inflammatory and anti-cancer activities. We fed male C57BL/6 mice purified AIN93G diets containing no additions, GKB or the GKB-rich fraction of an ethanol extract (GE) from GK to determine if these diets would slow or prevent either inflammation or inflammation-enhanced colon cancer, using the dextran sulfate sodium/azoxymethane mouse model. The GKB (500 mu mol/kg diet daily) showed some anti-inflammatory activity, but GE, containing an equal dose of GKB, protected strongly against both inflammation and colon cancer, decreasing adenocarcinomas by 90%. These data support further research into GK as a promising potential anti-cancer agent. (C) 2012 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.subjectBIOACTIVITY-
dc.subjectINDUCTION-
dc.titleA polyacetylene-rich extract from Gymnaster koraiensis strongly inhibits colitis-associated colon cancer in mice-
dc.typeArticle-
dc.identifier.doi10.1016/j.fct.2012.11.049-
dc.description.journalClass1-
dc.identifier.bibliographicCitationFOOD AND CHEMICAL TOXICOLOGY, v.53, pp.235 - 239-
dc.citation.titleFOOD AND CHEMICAL TOXICOLOGY-
dc.citation.volume53-
dc.citation.startPage235-
dc.citation.endPage239-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000322924700033-
dc.identifier.scopusid2-s2.0-84871970447-
dc.relation.journalWebOfScienceCategoryFood Science & Technology-
dc.relation.journalWebOfScienceCategoryToxicology-
dc.relation.journalResearchAreaFood Science & Technology-
dc.relation.journalResearchAreaToxicology-
dc.type.docTypeArticle-
dc.subject.keywordPlusBIOACTIVITY-
dc.subject.keywordPlusINDUCTION-
dc.subject.keywordAuthorAzoxymethane-
dc.subject.keywordAuthorColon cancer-
dc.subject.keywordAuthorDextran sulfate sodium-
dc.subject.keywordAuthorPrevention-
dc.subject.keywordAuthorInflammation-
dc.subject.keywordAuthorPolyacetylene-
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