Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Butler, Shannon M. | - |
dc.contributor.author | Wallig, Matthew A. | - |
dc.contributor.author | Nho, Chu Won | - |
dc.contributor.author | Pan, Cheol-Ho | - |
dc.contributor.author | Lee, Eun-Ha | - |
dc.contributor.author | Jung, Sang Hoon | - |
dc.contributor.author | Jeffery, Elizabeth H. | - |
dc.date.accessioned | 2024-01-20T13:00:28Z | - |
dc.date.available | 2024-01-20T13:00:28Z | - |
dc.date.created | 2021-09-01 | - |
dc.date.issued | 2013-03 | - |
dc.identifier.issn | 0278-6915 | - |
dc.identifier.uri | https://pubs.kist.re.kr/handle/201004/128293 | - |
dc.description.abstract | Gymnaster koraiensis (GK) is a Korean herb used in folk medicine and recently found to positively impact liver health. Because GK contains polyacetylenes and because other polyacetylenes have been found to exhibit anti-inflammatory and anti-cancer activities, we hypothesized that the polyacetylene gymnasterkoreayne B (GKB), known to increase hepatic detoxification enzymes, may also exert anti-inflammatory and anti-cancer activities. We fed male C57BL/6 mice purified AIN93G diets containing no additions, GKB or the GKB-rich fraction of an ethanol extract (GE) from GK to determine if these diets would slow or prevent either inflammation or inflammation-enhanced colon cancer, using the dextran sulfate sodium/azoxymethane mouse model. The GKB (500 mu mol/kg diet daily) showed some anti-inflammatory activity, but GE, containing an equal dose of GKB, protected strongly against both inflammation and colon cancer, decreasing adenocarcinomas by 90%. These data support further research into GK as a promising potential anti-cancer agent. (C) 2012 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.subject | BIOACTIVITY | - |
dc.subject | INDUCTION | - |
dc.title | A polyacetylene-rich extract from Gymnaster koraiensis strongly inhibits colitis-associated colon cancer in mice | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.fct.2012.11.049 | - |
dc.description.journalClass | 1 | - |
dc.identifier.bibliographicCitation | FOOD AND CHEMICAL TOXICOLOGY, v.53, pp.235 - 239 | - |
dc.citation.title | FOOD AND CHEMICAL TOXICOLOGY | - |
dc.citation.volume | 53 | - |
dc.citation.startPage | 235 | - |
dc.citation.endPage | 239 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.identifier.wosid | 000322924700033 | - |
dc.identifier.scopusid | 2-s2.0-84871970447 | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | BIOACTIVITY | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordAuthor | Azoxymethane | - |
dc.subject.keywordAuthor | Colon cancer | - |
dc.subject.keywordAuthor | Dextran sulfate sodium | - |
dc.subject.keywordAuthor | Prevention | - |
dc.subject.keywordAuthor | Inflammation | - |
dc.subject.keywordAuthor | Polyacetylene | - |
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