DSpace at KISTKIST Article2013

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dc.contributor.authorHayat, Faisal-
dc.contributor.authorYoo, Euna-
dc.contributor.authorRhim, Hyewhon-
dc.contributor.authorChoo, Hea-Young Park-
dc.date.accessioned2024-01-20T13:02:07Z-
dc.date.available2024-01-20T13:02:07Z-
dc.date.created2022-01-25-
dc.date.issued2013-02-
dc.identifier.issn0253-2964-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/128375-
dc.description.abstractA novel series of aryl sulfonylpiperazine derivatives (5-15) were synthesized as 5-HT6 ligands. In vitro assay was evaluated by measuring the 5-HT-induced Ca2+ increases using HeLa cell line expressing the cloned human 5-HT6 receptor, and the compound 13 showed potent 5-HT6 receptor antagonistic effect with IC50 value of 3.9 mu M. Compound 13 also showed good selectivity on the 5-HT6 over 5-HT4 and 5-HT7 receptors.-
dc.languageEnglish-
dc.publisherKOREAN CHEMICAL SOC-
dc.titleSynthesis and Inhibition Effects on 5-HT6 Receptor of Benzothiazole Derivatives-
dc.typeArticle-
dc.identifier.doi10.5012/bkcs.2013.34.2.495-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.34, no.2, pp.495 - 499-
dc.citation.titleBULLETIN OF THE KOREAN CHEMICAL SOCIETY-
dc.citation.volume34-
dc.citation.number2-
dc.citation.startPage495-
dc.citation.endPage499-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
dc.identifier.wosid000316430200031-
dc.identifier.scopusid2-s2.0-84874525087-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusCENTRAL-NERVOUS-SYSTEM-
dc.subject.keywordPlusSEROTONIN RECEPTOR-
dc.subject.keywordPlusMOLECULAR-CLONING-
dc.subject.keywordPlusRAT-
dc.subject.keywordPlusLOCALIZATION-
dc.subject.keywordPlusANTAGONISTS-
dc.subject.keywordPlusLIGANDS-
dc.subject.keywordPlusPHARMACOLOGY-
dc.subject.keywordPlusMUTAGENESIS-
dc.subject.keywordPlusPROGRESS-
dc.subject.keywordAuthorSulfonamide-
dc.subject.keywordAuthorN-Methyl piperazine-
dc.subject.keywordAuthor5-HT6 receptor antagonist-
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