Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Shafioul, Azam Sharif Mohammed | - |
dc.contributor.author | Pyo, Jung In | - |
dc.contributor.author | Kim, Kwan Soo | - |
dc.contributor.author | Cheong, Chan Seong | - |
dc.date.accessioned | 2024-01-20T13:31:22Z | - |
dc.date.available | 2024-01-20T13:31:22Z | - |
dc.date.created | 2021-09-05 | - |
dc.date.issued | 2012-12 | - |
dc.identifier.issn | 1381-1177 | - |
dc.identifier.uri | https://pubs.kist.re.kr/handle/201004/128585 | - |
dc.description.abstract | Natural R-(-)-xanthorrhizol possess a number of therapeutic activities including anti-cancer. The pharmacokinetic properties of that poorly aqueous soluble compound could be improved by incorporating it into polymeric materials. Glycerol can produce a functionalized polymer through a polycondensation process. Enzymatic polycondensation of glycerol and divinylesters was studied and xanthorrhizol was covalently loaded via a butanedioate linker to the polymer backbone. It was observed that xanthorrhizol loading to the polymer backbone increases with the increasing of the chain length of a dioate moiety. Enzyme-mediated xanthorrhizol release from a polymer backbone shows that the polymeric prodrug is able to release xanthorrhizol in a sustained manner. Therefore, the approach described here might be valuable for controlled loading and release of such phenolic sesquiterpenes from the polymeric prodrug. (C) 2012 Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ELSEVIER | - |
dc.subject | CURCUMA-XANTHORRHIZA | - |
dc.subject | DIVINYL SEBACATE | - |
dc.subject | POLYESTERS | - |
dc.subject | POLYMERIZATION | - |
dc.subject | DELIVERY | - |
dc.title | Synthesis of poly (glycerol-co-dioate-co-butanedioate-co-xanthorrhizol) ester and a study of chain length effect on pendant group loading | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.molcatb.2012.05.022 | - |
dc.description.journalClass | 1 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, v.84, pp.198 - 204 | - |
dc.citation.title | JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC | - |
dc.citation.volume | 84 | - |
dc.citation.startPage | 198 | - |
dc.citation.endPage | 204 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.identifier.wosid | 000309573100033 | - |
dc.identifier.scopusid | 2-s2.0-84866347250 | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.type.docType | Article; Proceedings Paper | - |
dc.subject.keywordPlus | CURCUMA-XANTHORRHIZA | - |
dc.subject.keywordPlus | DIVINYL SEBACATE | - |
dc.subject.keywordPlus | POLYESTERS | - |
dc.subject.keywordPlus | POLYMERIZATION | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordAuthor | Enzyme | - |
dc.subject.keywordAuthor | Polycondensation | - |
dc.subject.keywordAuthor | Pendant group loading | - |
dc.subject.keywordAuthor | Drug delivery system | - |
dc.subject.keywordAuthor | Xanthorrhizol | - |
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