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dc.contributor.authorShafioul, Azam Sharif Mohammed-
dc.contributor.authorPyo, Jung In-
dc.contributor.authorKim, Kwan Soo-
dc.contributor.authorCheong, Chan Seong-
dc.date.accessioned2024-01-20T13:31:22Z-
dc.date.available2024-01-20T13:31:22Z-
dc.date.created2021-09-05-
dc.date.issued2012-12-
dc.identifier.issn1381-1177-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/128585-
dc.description.abstractNatural R-(-)-xanthorrhizol possess a number of therapeutic activities including anti-cancer. The pharmacokinetic properties of that poorly aqueous soluble compound could be improved by incorporating it into polymeric materials. Glycerol can produce a functionalized polymer through a polycondensation process. Enzymatic polycondensation of glycerol and divinylesters was studied and xanthorrhizol was covalently loaded via a butanedioate linker to the polymer backbone. It was observed that xanthorrhizol loading to the polymer backbone increases with the increasing of the chain length of a dioate moiety. Enzyme-mediated xanthorrhizol release from a polymer backbone shows that the polymeric prodrug is able to release xanthorrhizol in a sustained manner. Therefore, the approach described here might be valuable for controlled loading and release of such phenolic sesquiterpenes from the polymeric prodrug. (C) 2012 Elsevier B.V. All rights reserved.-
dc.languageEnglish-
dc.publisherELSEVIER-
dc.subjectCURCUMA-XANTHORRHIZA-
dc.subjectDIVINYL SEBACATE-
dc.subjectPOLYESTERS-
dc.subjectPOLYMERIZATION-
dc.subjectDELIVERY-
dc.titleSynthesis of poly (glycerol-co-dioate-co-butanedioate-co-xanthorrhizol) ester and a study of chain length effect on pendant group loading-
dc.typeArticle-
dc.identifier.doi10.1016/j.molcatb.2012.05.022-
dc.description.journalClass1-
dc.identifier.bibliographicCitationJOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, v.84, pp.198 - 204-
dc.citation.titleJOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC-
dc.citation.volume84-
dc.citation.startPage198-
dc.citation.endPage204-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000309573100033-
dc.identifier.scopusid2-s2.0-84866347250-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryChemistry, Physical-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle; Proceedings Paper-
dc.subject.keywordPlusCURCUMA-XANTHORRHIZA-
dc.subject.keywordPlusDIVINYL SEBACATE-
dc.subject.keywordPlusPOLYESTERS-
dc.subject.keywordPlusPOLYMERIZATION-
dc.subject.keywordPlusDELIVERY-
dc.subject.keywordAuthorEnzyme-
dc.subject.keywordAuthorPolycondensation-
dc.subject.keywordAuthorPendant group loading-
dc.subject.keywordAuthorDrug delivery system-
dc.subject.keywordAuthorXanthorrhizol-
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