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dc.contributor.authorCho, Hye Jung-
dc.contributor.authorEl-Gamal, Mohammed I.-
dc.contributor.authorOh, Chang-Hyun-
dc.contributor.authorLee, So Ha-
dc.contributor.authorKim, Garam-
dc.contributor.authorHong, Jun Hee-
dc.contributor.authorChoi, Hong Seok-
dc.contributor.authorYoo, Kyung Ho-
dc.date.accessioned2024-01-20T13:32:37Z-
dc.date.available2024-01-20T13:32:37Z-
dc.date.created2021-09-05-
dc.date.issued2012-11-20-
dc.identifier.issn0253-2964-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/128644-
dc.description.abstractA series of new diarylureas possessing aminoisoquinoline scaffold was synthesized, and their in vitro antiproliferative activity against A375P human melanoma cell line was tested. Compounds 1d, 1l, 1n, 1p, 1q, and 1t showed superior potency against A375P to Sorafenib. The highest potency was shown by compound 1p possessing 3,5-bis(trifluoromethyl)phenyl terminal ring with IC50 value of 0.41 mu M.-
dc.languageEnglish-
dc.publisherWILEY-V C H VERLAG GMBH-
dc.subjectDESIGN-
dc.subjectDIARYLAMIDES-
dc.subjectDIARYLUREAS-
dc.subjectDIAGNOSIS-
dc.titleSynthesis and Antiproliferative Activity of New Aminoisoquinolinylurea Derivatives against Melanoma Cell Line-
dc.typeArticle-
dc.identifier.doi10.5012/bkcs.2012.33.11.3635-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.33, no.11, pp.3635 - 3639-
dc.citation.titleBULLETIN OF THE KOREAN CHEMICAL SOCIETY-
dc.citation.volume33-
dc.citation.number11-
dc.citation.startPage3635-
dc.citation.endPage3639-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
dc.identifier.kciidART001711840-
dc.identifier.wosid000311816000020-
dc.identifier.scopusid2-s2.0-84870026320-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusDESIGN-
dc.subject.keywordPlusDIARYLAMIDES-
dc.subject.keywordPlusDIARYLUREAS-
dc.subject.keywordPlusDIAGNOSIS-
dc.subject.keywordAuthorA375P-
dc.subject.keywordAuthorAminoisoquinoline-
dc.subject.keywordAuthorAnticancer-
dc.subject.keywordAuthorDiarylurea-
dc.subject.keywordAuthorMelanoma-
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