Characterization of Surface Properties and Cytocompatibility of Ion-etched Chitosan Films

Authors
Ko, Young GunYu, Seong MiPark, Sang JoonChun, Heung JaeKim, Chun-Ho
Issue Date
2012-05-08
Publisher
AMER CHEMICAL SOC
Citation
LANGMUIR, v.28, no.18, pp.7223 - 7232
Abstract
Surface modification of biomaterials has been highlighted by biomedical engineers as a facile method for improving cell-biomaterial interactions without the expense and time required to develop new materials. In the present study, we investigated the influence of ion-etching on the surface characteristics of chitosan films using XPS and ATR FT-IR. The physiological behavior of human dermal fibroblasts (hDFs) grown on such surfaces was studied by evaluating adhesive and proliferative properties, and by examining surface morphologies of hDFs using AFM. hDFs displayed different shapes depending on the ion-etching time. hDFs grown on chitosan films ion-etched for 5 min displayed better development of lamellipodia and filopodia around the hDF periphery than did cells grown on nonmodified chitosan film, whereas hDFs did not spread well on films ion-etched for 20 min. Films ion-etched for 5 min or less had higher NH2 and COOH contents, leading to enhanced hDF adhesion and proliferation.
Keywords
POLYMER SURFACES; DERMAL SCAFFOLD; FT-IR; ADHESION; PLASMA; BIOCOMPATIBILITY; BIOMATERIALS; CELLS; PROLIFERATION; KERATINOCYTES; POLYMER SURFACES; DERMAL SCAFFOLD; FT-IR; ADHESION; PLASMA; BIOCOMPATIBILITY; BIOMATERIALS; CELLS; PROLIFERATION; KERATINOCYTES
ISSN
0743-7463
URI
https://pubs.kist.re.kr/handle/201004/129262
DOI
10.1021/la204176j
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KIST Article > 2012
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