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dc.contributor.authorShin, Kyoungjin-
dc.contributor.authorChin, Jungwook-
dc.contributor.authorHahn, Dongyup-
dc.contributor.authorLee, Jaehwan-
dc.contributor.authorHwang, Hoosang-
dc.contributor.authorWon, Dong Hwan-
dc.contributor.authorHam, Jungyeob-
dc.contributor.authorChoi, Hyukjae-
dc.contributor.authorKang, Eunsoo-
dc.contributor.authorKim, Hiyoung-
dc.contributor.authorJu, Moon Kyeong-
dc.contributor.authorNam, Sang-Jip-
dc.contributor.authorKang, Heonjoong-
dc.date.accessioned2024-01-20T15:04:18Z-
dc.date.available2024-01-20T15:04:18Z-
dc.date.created2021-08-31-
dc.date.issued2012-04-
dc.identifier.issn0039-128X-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/129418-
dc.description.abstractThree new steroids 3-oxocholest-1,22-dien-12 beta-ol (1), 3-oxocholest-1,4-dien-20 beta-ol (2), 3-oxocholest-1,4-dien-12 beta-ol (3), and three known steroids (20S)-20-Hydroxyergosta-1,4,24(28)-trien-3-one (4)[7a], 5 alpha,8 alpha-Epidioxycholesta-6,22-dien-3 beta-ol (5) [10] and 5-cholestene-3 beta,12 beta-diol (6) 1111 were isolated from a soft coral Dendronephthya gigantea. Their chemical structures and relative stereochemistry were elucidated by the analysis of HRMS and 2-D NMR spectroscopic data. The steroids 1 and 2 showed notable inhibitory activity against farnesoid X-activated receptor (FXR) with IC50's 14 and 15 mu M. (C) 2012 Elsevier Inc. All rights reserved.-
dc.languageEnglish-
dc.publisherELSEVIER SCIENCE INC-
dc.subjectSTRUCTURE ELUCIDATION-
dc.subjectURSODEOXYCHOLIC ACID-
dc.titleSterols from a soft coral, Dendronephthya gigantea as farnesoid X-activated receptor antagonists-
dc.typeArticle-
dc.identifier.doi10.1016/j.steroids.2011.12.027-
dc.description.journalClass1-
dc.identifier.bibliographicCitationSTEROIDS, v.77, no.5, pp.355 - 359-
dc.citation.titleSTEROIDS-
dc.citation.volume77-
dc.citation.number5-
dc.citation.startPage355-
dc.citation.endPage359-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000303084000001-
dc.identifier.scopusid2-s2.0-84862790074-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryEndocrinology & Metabolism-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaEndocrinology & Metabolism-
dc.type.docTypeArticle-
dc.subject.keywordPlusSTRUCTURE ELUCIDATION-
dc.subject.keywordPlusURSODEOXYCHOLIC ACID-
dc.subject.keywordAuthorCholestasis-
dc.subject.keywordAuthorDendronephthya gigantea-
dc.subject.keywordAuthorFarnesoid X-activated receptor-
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