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dc.contributor.authorYuk, Soon Hong-
dc.contributor.authorOh, Keun Sang-
dc.contributor.authorKim, Seung Ki-
dc.contributor.authorLee, Jin Ho-
dc.contributor.authorCho, Sun Hang-
dc.contributor.authorKim, Kwangmeyung-
dc.contributor.authorJeon, Hyesung-
dc.contributor.authorKwon, Ick Chan-
dc.date.accessioned2024-01-20T15:05:35Z-
dc.date.available2024-01-20T15:05:35Z-
dc.date.created2021-09-05-
dc.date.issued2012-03-
dc.identifier.issn1598-5032-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/129469-
dc.description.abstractThe Pluronic/poly(ethylene glycol) composite nanoparticles (NPs) composed of Pluronic F-68, liquid poly(ethylene glycol) (PEG; molecular weight, 400) and human growth hormone (hGH) were stabilized with the vesicle fusion. When hGH-loaded Pluronic/PEG composite NPs were mixed with vesicles in the aqueous medium, hGH-loaded Pluronic/PEG composite NPs were incorporated into vesicles to form multi-core vesicle NPs. The morphology and size distribution of multi-core vesicle NPs were observed using field emission scanning electron microscopy, cryo-transmission electron microscopy, and a particle size analyzer. When multi-core vesicle NPs were applied as a delivery system for the protein drug, a sustained release pattern of hGH was observed.-
dc.languageEnglish-
dc.publisherPOLYMER SOC KOREA-
dc.subjectGH-DEFICIENT PATIENTS-
dc.subjectGROWTH-HORMONE GH-
dc.subjectCOPOLYMER-
dc.subjectFUSION-
dc.subjectENCAPSULATION-
dc.subjectMICROSPHERES-
dc.subjectSPECTROSCOPY-
dc.subjectSTABILITY-
dc.subjectBILAYER-
dc.subjectSYSTEMS-
dc.titleMulti-core vesicle nanoparticles for controlled delivery of protein drug-
dc.typeArticle-
dc.identifier.doi10.1007/s13233-012-0053-y-
dc.description.journalClass1-
dc.identifier.bibliographicCitationMACROMOLECULAR RESEARCH, v.20, no.3, pp.309 - 312-
dc.citation.titleMACROMOLECULAR RESEARCH-
dc.citation.volume20-
dc.citation.number3-
dc.citation.startPage309-
dc.citation.endPage312-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
dc.identifier.kciidART001643265-
dc.identifier.wosid000302262000013-
dc.identifier.scopusid2-s2.0-84862189747-
dc.relation.journalWebOfScienceCategoryPolymer Science-
dc.relation.journalResearchAreaPolymer Science-
dc.type.docTypeArticle-
dc.subject.keywordPlusGH-DEFICIENT PATIENTS-
dc.subject.keywordPlusGROWTH-HORMONE GH-
dc.subject.keywordPlusCOPOLYMER-
dc.subject.keywordPlusFUSION-
dc.subject.keywordPlusENCAPSULATION-
dc.subject.keywordPlusMICROSPHERES-
dc.subject.keywordPlusSPECTROSCOPY-
dc.subject.keywordPlusSTABILITY-
dc.subject.keywordPlusBILAYER-
dc.subject.keywordPlusSYSTEMS-
dc.subject.keywordAuthorhuman growth hormone-
dc.subject.keywordAuthorPluronic/PEG composite NPs-
dc.subject.keywordAuthormulti-core vesicle NPs-
dc.subject.keywordAuthorpeptide drug-
dc.subject.keywordAuthorsustained release-
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KIST Article > 2012
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