Novel Cyanine Dyes with Vinylsulfone Group for Labeling Biomolecules

Authors
Park, Jin WooKim, YoungSooLee, Kee-JungKim, Dong Jin
Issue Date
2012-03
Publisher
AMER CHEMICAL SOC
Citation
BIOCONJUGATE CHEMISTRY, v.23, no.3, pp.350 - 362
Abstract
Novel vinylsulfone cyanine dyes (em. 550-850 nm) were designed and synthesized for fluorescent labeling of biomolecules via 1,2-addition reaction in aqueous conditions. Due to the virtue of chemical structures of both fluorophore and reactive group, these dyes could be significantly stable and reactive in various aqueous/organic conditions. A wide variety of pH, temperature, buffer concentration, and protein were tested for the optimal labeling condition.
Keywords
N-HYDROXYSUCCINIMIDE ESTERS; REAGENTS; KINETICS; PROBES; DNA; N-HYDROXYSUCCINIMIDE ESTERS; REAGENTS; KINETICS; PROBES; DNA; 형광물질; 염료; fluorescence; vinylsulfone
ISSN
1043-1802
URI
https://pubs.kist.re.kr/handle/201004/129480
DOI
10.1021/bc200232d
Appears in Collections:
KIST Article > 2012
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