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dc.contributor.authorYuk, Soon Hong-
dc.contributor.authorOh, Keun Sang-
dc.contributor.authorKoo, Heebeom-
dc.contributor.authorJeon, Hyesung-
dc.contributor.authorKim, Kwangmeyung-
dc.contributor.authorKwon, Ick Chan-
dc.date.accessioned2024-01-20T16:02:30Z-
dc.date.available2024-01-20T16:02:30Z-
dc.date.created2021-09-05-
dc.date.issued2011-11-
dc.identifier.issn0142-9612-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/129840-
dc.description.abstractThe Pluronic nanoparticles (NPs) composed of Pluronic (F-68) and liquid polyethylene glycol (PEG, molecular wt: 400) containing docetaxel (DTX) were stabilized with the vesicle fusion. When DTX-loaded Pluronic NPs were mixed with vesicles in the aqueous medium, DTX-loaded Pluronic NPs were incorporated into vesicles to form multi-core vesicle NPs. The morphology and size distribution of multi-core vesicle NPs were observed using FE-SEM, cryo-TEM and a particle size analyzer. To apply multi-core vesicle NPs as a delivery system for DTX, a model anti-cancer drug, the release pattern of DTX was observed and the tumor growth was monitored by injecting the DTX-loaded multi-core vesicle NPs into the tail veins of tumor-bearing mice. We also evaluated the time-dependent excretion profile, in vivo biodistribution, circulation time, and tumor targeting capability of multi-core vesicle NPs using a non-invasive live animal imaging technology. (C) 2011 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherELSEVIER SCI LTD-
dc.subjectPOLYETHYLENE-GLYCOL-
dc.subjectLIPOSOME FUSION-
dc.subjectLUNG-CANCER-
dc.subjectDOCETAXEL-
dc.subjectPACLITAXEL-
dc.subjectBILAYER-
dc.subjectINCREASES-
dc.subjectRELEASE-
dc.titleMulti-core vesicle nanoparticles based on vesicle fusion for delivery of chemotherapic drugs-
dc.typeArticle-
dc.identifier.doi10.1016/j.biomaterials.2011.07.017-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBIOMATERIALS, v.32, no.31, pp.7924 - 7931-
dc.citation.titleBIOMATERIALS-
dc.citation.volume32-
dc.citation.number31-
dc.citation.startPage7924-
dc.citation.endPage7931-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000295072600018-
dc.identifier.scopusid2-s2.0-80051817296-
dc.relation.journalWebOfScienceCategoryEngineering, Biomedical-
dc.relation.journalWebOfScienceCategoryMaterials Science, Biomaterials-
dc.relation.journalResearchAreaEngineering-
dc.relation.journalResearchAreaMaterials Science-
dc.type.docTypeArticle-
dc.subject.keywordPlusPOLYETHYLENE-GLYCOL-
dc.subject.keywordPlusLIPOSOME FUSION-
dc.subject.keywordPlusLUNG-CANCER-
dc.subject.keywordPlusDOCETAXEL-
dc.subject.keywordPlusPACLITAXEL-
dc.subject.keywordPlusBILAYER-
dc.subject.keywordPlusINCREASES-
dc.subject.keywordPlusRELEASE-
dc.subject.keywordAuthorDrug delivery-
dc.subject.keywordAuthorMulti-core vesicle nanoparticles-
dc.subject.keywordAuthorPluronic-
dc.subject.keywordAuthorDocetaxel-
dc.subject.keywordAuthorChemotherapy-
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