Design and Synthesis of 3-(3-Chloro-4-substituted phenyl)-4-(pyridin-4-yl)-1H-pyrazole-1-carboxamide Derivatives and Their Antiproliferative Activity Against Melanoma Cell Line

Authors
El-Gamal, Mohammed I.Oh, Chang-Hyun
Issue Date
2011-03-20
Publisher
WILEY-V C H VERLAG GMBH
Citation
BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.32, no.3, pp.821 - 828
Abstract
Design and synthesis of new 3,4-diarylpyrazole-1-carboxamide derivatives are described. Their antiproliferative activity against A375 human melanoma cell line was tested and the effect of substituents on the diarylpyrazole scaffold was investigated. The pharmacological results indicated that most of the synthesized compounds showed moderate activity against A375, compared with Sorafenib. On the other hand, compounds Ia, Ie, IIb, and IIh were more potent than Sorafenib. In addition, compound IIa was equipotent to Sorafenib. Among all of these derivatives, compound IIb which has diethylamino and phenolic moieties showed the most potent antiproliferative activity against A375 human melanoma cell line. Virtual screening was carried out through docking of the most potent compound IIb into the domain of V600E-b-Raf and the binding mode was studied.
Keywords
REFRACTORY SOLID TUMORS; FACTOR RECEPTOR INHIBITOR; RAF KINASE; METASTATIC MELANOMA; PHASE-I; BAY-43-9006; SORAFENIB; THERAPY; PHARMACOKINETICS; INTERLEUKIN-2; REFRACTORY SOLID TUMORS; FACTOR RECEPTOR INHIBITOR; RAF KINASE; METASTATIC MELANOMA; PHASE-I; BAY-43-9006; SORAFENIB; THERAPY; PHARMACOKINETICS; INTERLEUKIN-2; Antiproliferative activity; 1H-Pyrazole-1-carboxamide; 3,4-Diarylpyrazole; A375; Melanoma
ISSN
0253-2964
URI
https://pubs.kist.re.kr/handle/201004/130517
DOI
10.5012/bkcs.2011.32.3.821
Appears in Collections:
KIST Article > 2011
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