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dc.contributor.authorLee, Hee Ju-
dc.contributor.authorLee, Joo Young-
dc.contributor.authorKim, Sang Min-
dc.contributor.authorNho, Chu Won-
dc.contributor.authorJung, Sang Hoon-
dc.contributor.authorSong, Dae-Geun-
dc.contributor.authorKim, Chul Young-
dc.contributor.authorPan, Cheol-Ho-
dc.date.accessioned2024-01-20T18:03:27Z-
dc.date.available2024-01-20T18:03:27Z-
dc.date.created2021-09-05-
dc.date.issued2010-12-
dc.identifier.issn1738-2203-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/130872-
dc.description.abstractThe ethyl acetate fraction of Artemisia dubia showed a potent inhibitory activity on recombinant human AKR1B10 (rh AKR1B10). Due to its potency, subsequent purification of ethyl acetate fraction led to seven compounds including five dicaffeoylquinic acid (DCQA) derivatives. Compounds were identified as 3,4-dihydroxybenzoic acid (1), quercetin 3-O-beta-glucose (2), 3,4-DCQA (3), 3,5-DCQA (4), 4,5-DCQA (5), 3,5-DCQA methyl ester (6), and 4,5-DCQA methyl ester (7). A series of DCQA derivatives (3-7) showed inhibitory activity on rhAKR1B10 in the range of IC50 1.24-2.29 1. mu M, whereas 3,4-dihydroxybenzoic acid and quercetin 3-O-beta-glucose showed no inhibitory activity on rhAKR1B10.-
dc.languageEnglish-
dc.publisherKOREAN SOC APPLIED BIOLOGICAL CHEMISTRY-
dc.subjectCANCER-CELLS-
dc.subjectBREAST-CANCER-
dc.subjectB10-
dc.subjectAKR1B10-
dc.subjectGENE-
dc.subjectIDENTIFICATION-
dc.subjectDERIVATIVES-
dc.subjectCARCINOMAS-
dc.subjectLIVER-
dc.titleInhibitory Effects of Dicaffeoylquinic Acids from Artemisia dubia on Aldo-keto Reductase Family 1B10-
dc.typeArticle-
dc.identifier.doi10.3839/jksabc.2010.125-
dc.description.journalClass1-
dc.identifier.bibliographicCitationJOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY, v.53, no.6, pp.826 - 830-
dc.citation.titleJOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY-
dc.citation.volume53-
dc.citation.number6-
dc.citation.startPage826-
dc.citation.endPage830-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
dc.identifier.kciidART001514785-
dc.identifier.wosid000286407900025-
dc.identifier.scopusid2-s2.0-78751481240-
dc.relation.journalWebOfScienceCategoryFood Science & Technology-
dc.relation.journalResearchAreaFood Science & Technology-
dc.type.docTypeArticle-
dc.subject.keywordPlusCANCER-CELLS-
dc.subject.keywordPlusBREAST-CANCER-
dc.subject.keywordPlusB10-
dc.subject.keywordPlusAKR1B10-
dc.subject.keywordPlusGENE-
dc.subject.keywordPlusIDENTIFICATION-
dc.subject.keywordPlusDERIVATIVES-
dc.subject.keywordPlusCARCINOMAS-
dc.subject.keywordPlusLIVER-
dc.subject.keywordAuthorAKR1B10-
dc.subject.keywordAuthoraldose reductase-like-
dc.subject.keywordAuthoranticancer-
dc.subject.keywordAuthorDCQA-
dc.subject.keywordAuthordicaffeoylquinic acid-
dc.subject.keywordAuthorArtemisia dubia-
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