Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kwon, Hak Cheol | - |
dc.contributor.author | Espindola, Ana Paula D. M. | - |
dc.contributor.author | Park, Jin-Soo | - |
dc.contributor.author | Prieto-Davo, Alejandra | - |
dc.contributor.author | Rose, Mickea | - |
dc.contributor.author | Jensen, Paul R. | - |
dc.contributor.author | Fenical, William | - |
dc.date.accessioned | 2024-01-20T18:03:31Z | - |
dc.date.available | 2024-01-20T18:03:31Z | - |
dc.date.created | 2021-09-05 | - |
dc.date.issued | 2010-12 | - |
dc.identifier.issn | 0163-3864 | - |
dc.identifier.uri | https://pubs.kist.re.kr/handle/201004/130876 | - |
dc.description.abstract | Five new farnesyl-alpha-nitropyrroles, nitropyrrolins A-E (1-5), were isolated from the saline culture of the marine actinomycete strain CNQ-509. This strain belongs to the "MAR4" group of marine actinomycetes, which have been demonstrated to be a rich source of hybrid isoprenoid secondary metabolites. The structures of the nitropyrrolins are composed of alpha-nitropyrroles with functionalized farnesyl groups at the C-4 position. These compounds are the first examples of naturally occurring terpenyl-alpha-nitropyrroles. Chemical modifications, including one-step acetonide formation from an epoxide, and application of the modified Mosher method provided the full stereostructures and absolute configurations of these compounds. Several of the nitropyrrolins, nitropyrrolin D in particular, are cytotoxic toward HCT-116 human colon carcinoma cells, but show weak to little antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). | - |
dc.language | English | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | DISCOVERY | - |
dc.subject | INHIBITOR | - |
dc.title | Nitropyrrolins A-E, Cytotoxic Farnesyl-alpha-nitropyrroles from a Marine-Derived Bacterium within the Actinomycete Family Streptomycetaceae | - |
dc.type | Article | - |
dc.identifier.doi | 10.1021/np1006229 | - |
dc.description.journalClass | 1 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NATURAL PRODUCTS, v.73, no.12, pp.2047 - 2052 | - |
dc.citation.title | JOURNAL OF NATURAL PRODUCTS | - |
dc.citation.volume | 73 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 2047 | - |
dc.citation.endPage | 2052 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.identifier.wosid | 000285560000014 | - |
dc.identifier.scopusid | 2-s2.0-78650737399 | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | DISCOVERY | - |
dc.subject.keywordPlus | INHIBITOR | - |
dc.subject.keywordAuthor | Marine microorganism | - |
dc.subject.keywordAuthor | actinomycete | - |
dc.subject.keywordAuthor | novel compound | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.