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dc.contributor.authorKwon, Hak Cheol-
dc.contributor.authorEspindola, Ana Paula D. M.-
dc.contributor.authorPark, Jin-Soo-
dc.contributor.authorPrieto-Davo, Alejandra-
dc.contributor.authorRose, Mickea-
dc.contributor.authorJensen, Paul R.-
dc.contributor.authorFenical, William-
dc.date.accessioned2024-01-20T18:03:31Z-
dc.date.available2024-01-20T18:03:31Z-
dc.date.created2021-09-05-
dc.date.issued2010-12-
dc.identifier.issn0163-3864-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/130876-
dc.description.abstractFive new farnesyl-alpha-nitropyrroles, nitropyrrolins A-E (1-5), were isolated from the saline culture of the marine actinomycete strain CNQ-509. This strain belongs to the "MAR4" group of marine actinomycetes, which have been demonstrated to be a rich source of hybrid isoprenoid secondary metabolites. The structures of the nitropyrrolins are composed of alpha-nitropyrroles with functionalized farnesyl groups at the C-4 position. These compounds are the first examples of naturally occurring terpenyl-alpha-nitropyrroles. Chemical modifications, including one-step acetonide formation from an epoxide, and application of the modified Mosher method provided the full stereostructures and absolute configurations of these compounds. Several of the nitropyrrolins, nitropyrrolin D in particular, are cytotoxic toward HCT-116 human colon carcinoma cells, but show weak to little antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA).-
dc.languageEnglish-
dc.publisherAMER CHEMICAL SOC-
dc.subjectDISCOVERY-
dc.subjectINHIBITOR-
dc.titleNitropyrrolins A-E, Cytotoxic Farnesyl-alpha-nitropyrroles from a Marine-Derived Bacterium within the Actinomycete Family Streptomycetaceae-
dc.typeArticle-
dc.identifier.doi10.1021/np1006229-
dc.description.journalClass1-
dc.identifier.bibliographicCitationJOURNAL OF NATURAL PRODUCTS, v.73, no.12, pp.2047 - 2052-
dc.citation.titleJOURNAL OF NATURAL PRODUCTS-
dc.citation.volume73-
dc.citation.number12-
dc.citation.startPage2047-
dc.citation.endPage2052-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000285560000014-
dc.identifier.scopusid2-s2.0-78650737399-
dc.relation.journalWebOfScienceCategoryPlant Sciences-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryPharmacology & Pharmacy-
dc.relation.journalResearchAreaPlant Sciences-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.type.docTypeArticle-
dc.subject.keywordPlusDISCOVERY-
dc.subject.keywordPlusINHIBITOR-
dc.subject.keywordAuthorMarine microorganism-
dc.subject.keywordAuthoractinomycete-
dc.subject.keywordAuthornovel compound-
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