DSpace at KISTKIST Article2010

Full metadata record

DC Field Value Language
dc.contributor.authorKo, Jaeyoung-
dc.contributor.authorHwang, Hoosang-
dc.contributor.authorChin, Jungwook-
dc.contributor.authorHahn, Dongyup-
dc.contributor.authorLee, Jaehwan-
dc.contributor.authorYang, Inho-
dc.contributor.authorShin, Kyoungjin-
dc.contributor.authorHam, Jungyeob-
dc.contributor.authorKang, Heonjoong-
dc.date.accessioned2024-01-20T18:31:05Z-
dc.date.available2024-01-20T18:31:05Z-
dc.date.created2021-09-05-
dc.date.issued2010-10-15-
dc.identifier.issn0960-894X-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/131000-
dc.description.abstractA novel class of natural PPAR agonists, 2,4-dimethyl-4-hydroxy-16-phenylhexadecanoic acid 1,4-lactone (1), were discovered in marine natural product libraries. The synthesis of 1 was accomplished starting from vinylmethyl ketone. Ring formation of the alpha,gamma dialkyl gamma-lactone was achieved via the stereo-controlled reaction of a ketyl radical anion with a chiral methacrylate. In the PPAR agonistic assay, the most potent of the four stereoisomers had EC(50) values of 12 mu M for mPPAR alpha, 9 mu M for mPPAR delta and > 100 mu M for mPPAR gamma. (c) 2010 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherPergamon Press Ltd.-
dc.subjectALPHA,GAMMA-SUBSTITUTED GAMMA-BUTYROLACTONES-
dc.subjectSAMARIUM(II) IODIDE-
dc.subjectAGONISTS-
dc.titleA stereo-controlled synthesis of 2,4-dimethyl-4-hydroxy-16-phenylhexadecanoic acid 1,4-lactone and its PPAR activities-
dc.typeArticle-
dc.identifier.doi10.1016/j.bmcl.2010.08.069-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBioorganic & Medicinal Chemistry Letters, v.20, no.20, pp.6017 - 6019-
dc.citation.titleBioorganic & Medicinal Chemistry Letters-
dc.citation.volume20-
dc.citation.number20-
dc.citation.startPage6017-
dc.citation.endPage6019-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000281963700013-
dc.identifier.scopusid2-s2.0-77956933869-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusALPHA,GAMMA-SUBSTITUTED GAMMA-BUTYROLACTONES-
dc.subject.keywordPlusSAMARIUM(II) IODIDE-
dc.subject.keywordPlusAGONISTS-
dc.subject.keywordAuthorNuclear receptor-
dc.subject.keywordAuthorPPAR alpha/delta dual agonist-
dc.subject.keywordAuthorMarine agonist-
Appears in Collections:
KIST Article > 2010
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML
Show Simple Item Record

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE