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dc.contributor.authorPark, Jin-Hun-
dc.contributor.authorChang, Jeong-Soo-
dc.contributor.authorEl-Gamal, Mohammed I.-
dc.contributor.authorChoi, Won-Kyoung-
dc.contributor.authorLee, Woong San-
dc.contributor.authorChung, Hye Jin-
dc.contributor.authorKim, Hyun-Il-
dc.contributor.authorCho, Young-Jin-
dc.contributor.authorLee, Bong Sang-
dc.contributor.authorJeon, Hong-Ryeol-
dc.contributor.authorLee, Yong Sup-
dc.contributor.authorChoi, Young Wook-
dc.contributor.authorLee, Jaehwi-
dc.contributor.authorOh, Chang-Hyun-
dc.date.accessioned2024-01-20T18:31:19Z-
dc.date.available2024-01-20T18:31:19Z-
dc.date.created2022-01-10-
dc.date.issued2010-10-01-
dc.identifier.issn0960-894X-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/131010-
dc.description.abstractSynthesis of novel amides and esters prodrugs of olmesartan is described. Their in vitro stability in rat plasma was tested. The results showed that the ester derivative IIa with n-octyl substituted dioxolone moiety was rapidly converted into olmesartan within 30 min. The pharmacokinetic parameters of IIa were studied and compared with those of olmesartan medoxomil. Compound IIa is proposed to be a promising prodrug of olmesartan. (C) 2010 Published by Elsevier Ltd.-
dc.languageEnglish-
dc.publisherPergamon Press Ltd.-
dc.subjectANGIOTENSIN-CONVERTING ENZYME-
dc.subjectII RECEPTOR ANTAGONISTS-
dc.subjectBLOCKER-
dc.subjectMEDOXOMIL-
dc.subjectRENIN-
dc.titleNovel amides and esters prodrugs of olmesartan: Synthesis, bioconversion, and pharmacokinetic evaluation-
dc.typeArticle-
dc.identifier.doi10.1016/j.bmcl.2010.07.089-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBioorganic & Medicinal Chemistry Letters, v.20, no.19, pp.5895 - 5899-
dc.citation.titleBioorganic & Medicinal Chemistry Letters-
dc.citation.volume20-
dc.citation.number19-
dc.citation.startPage5895-
dc.citation.endPage5899-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000281735600064-
dc.identifier.scopusid2-s2.0-77957561249-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusANGIOTENSIN-CONVERTING ENZYME-
dc.subject.keywordPlusII RECEPTOR ANTAGONISTS-
dc.subject.keywordPlusBLOCKER-
dc.subject.keywordPlusMEDOXOMIL-
dc.subject.keywordPlusRENIN-
dc.subject.keywordAuthorAntihypertensive-
dc.subject.keywordAuthorOlmesartan-
dc.subject.keywordAuthorOlmesartan medoxomil-
dc.subject.keywordAuthorProdrug-
dc.subject.keywordAuthorAmide-
dc.subject.keywordAuthorEster-
dc.subject.keywordAuthorPharmacokinetics-
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