DSpace at KIST: Synthesis and Antiviral Evaluation of 1 '-Branched-5 '-Norcarbocyclic Adenosine Phosphonic Acid Analogues

Synthesis and Antiviral Evaluation of 1 '-Branched-5 '-Norcarbocyclic Adenosine Phosphonic Acid Analogues

Citation: BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.31, no.9, pp.2473 - 2478

Abstract: Novel 1'-methyl-5'-norcarbocyclic adenosine phosphonic acid analogues were synthesized using an acyclic stereo-selective route from commercially available 3,3-diethoxy-propan-1-ol 4. The synthesized nucleoside phosphonate 19 and phosphonic acid 21 were subjected to antiviral screening against various viruses.

Keywords: ANTI-HIV ACTIVITY; MODIFIED NUCLEOSIDE PHOSPHONATES; HERBICIDAL ACTIVITY; NUCLEOTIDES; DESIGN; 2' -C-CYANO-2' -DEOXY-1-BETA-D-ARABINOFURANOSYLCYTOSINE; 1-(3-C-ETHYNYL-BETA-D-RIBO-PENTOFURANOSYL)CYTOSINE; 2' -DEOXY-2' -METHYLIDENECYTIDINE; RIBONUCLEOSIDES; DERIVATIVES; ANTI-HIV ACTIVITY; MODIFIED NUCLEOSIDE PHOSPHONATES; HERBICIDAL ACTIVITY; NUCLEOTIDES; DESIGN; 2' -C-CYANO-2' -DEOXY-1-BETA-D-ARABINOFURANOSYLCYTOSINE; 1-(3-C-ETHYNYL-BETA-D-RIBO-PENTOFURANOSYL)CYTOSINE; 2' -DEOXY-2' -METHYLIDENECYTIDINE; RIBONUCLEOSIDES; DERIVATIVES; Antiviral agent; 1 ' -Branched nucleoside; 5 ' -Nornucleoside; Phosphonic acid nucleoside

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