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dc.contributor.authorKim, Young-Joo-
dc.contributor.authorKo, Hyeonseok-
dc.contributor.authorPark, Jin-Soo-
dc.contributor.authorHan, Im-Ho-
dc.contributor.authorAmor, Evangeline C.-
dc.contributor.authorLee, Jong Wha-
dc.contributor.authorYang, Hyun Ok-
dc.date.accessioned2024-01-20T18:34:12Z-
dc.date.available2024-01-20T18:34:12Z-
dc.date.created2021-09-05-
dc.date.issued2010-09-
dc.identifier.issn1567-5769-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/131145-
dc.description.abstractThis study has found that dimethyl cardamonin (2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone; DMC), a naturally occurring chalcone, showed potent anti-inflammatory effects in vitro and in vivo. In a cellular model of inflammation, DMC inhibited production of nitric oxide (NO) and prostaglandin E-2 (PGE(2)) and attenuated expression of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6). IL-1 beta, inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2). DMC prevented nuclear translocation of the nuclear factor-kappa B (NF-kappa B) p65 subunit by reducing inhibitor of kappa B alpha (I-kappa B alpha) phosphorylation and degradation, which resulted in a suppression of NF-kappa B activities for its target genes. In a mouse model of endotoxin shock, the intraperitoneal injection (i.p.) of DMC (1-50 mg/kg) suppressed TNF-alpha, IL-6 and IL-1 beta secretion in LPS-induced mouse blood serum. These results suggest that DMC exerts anti-inflammatory effects through blocking NF-kappa B activation, therefore, DMC may act as an effective therapeutic strategy against a variety of inflammatory diseases. (C) 2010 Elsevier B.V. All rights reserved.-
dc.languageEnglish-
dc.publisherELSEVIER-
dc.subjectNITRIC-OXIDE SYNTHASE-
dc.subjectANTITUMOR-ACTIVITY-
dc.subjectPROTEIN-KINASE-
dc.subjectTRANSCRIPTION-
dc.subjectFLAVONOIDS-
dc.subjectINDUCTION-
dc.subjectCELLS-
dc.subjectINOS-
dc.subjectCYCLOOXYGENASE-2-
dc.subjectPHOSPHORYLATION-
dc.titleDimethyl cardamonin inhibits lipopolysaccharide-induced inflammatory factors through blocking NF-kappa B p65 activation-
dc.typeArticle-
dc.identifier.doi10.1016/j.intimp.2010.06.017-
dc.description.journalClass1-
dc.identifier.bibliographicCitationINTERNATIONAL IMMUNOPHARMACOLOGY, v.10, no.9, pp.1127 - 1134-
dc.citation.titleINTERNATIONAL IMMUNOPHARMACOLOGY-
dc.citation.volume10-
dc.citation.number9-
dc.citation.startPage1127-
dc.citation.endPage1134-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000281981600019-
dc.identifier.scopusid2-s2.0-77955920051-
dc.relation.journalWebOfScienceCategoryImmunology-
dc.relation.journalWebOfScienceCategoryPharmacology & Pharmacy-
dc.relation.journalResearchAreaImmunology-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.type.docTypeArticle-
dc.subject.keywordPlusNITRIC-OXIDE SYNTHASE-
dc.subject.keywordPlusANTITUMOR-ACTIVITY-
dc.subject.keywordPlusPROTEIN-KINASE-
dc.subject.keywordPlusTRANSCRIPTION-
dc.subject.keywordPlusFLAVONOIDS-
dc.subject.keywordPlusINDUCTION-
dc.subject.keywordPlusCELLS-
dc.subject.keywordPlusINOS-
dc.subject.keywordPlusCYCLOOXYGENASE-2-
dc.subject.keywordPlusPHOSPHORYLATION-
dc.subject.keywordAuthorDimethyl cardamonin-
dc.subject.keywordAuthorNO-
dc.subject.keywordAuthorPGE(2)-
dc.subject.keywordAuthoriNOS-
dc.subject.keywordAuthorCOX-2-
dc.subject.keywordAuthorNF-kappa B-
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