DSpace at KISTKIST Article2010

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dc.contributor.authorGu, Su Jin-
dc.contributor.authorLee, Jae Kyun-
dc.contributor.authorPae, Ae Nim-
dc.contributor.authorChung, Hye Jin-
dc.contributor.authorRhim, Hyewon-
dc.contributor.authorHan, So Yeob-
dc.contributor.authorMin, Sun-Joon-
dc.contributor.authorCho, Yong Seo-
dc.date.accessioned2024-01-20T19:05:21Z-
dc.date.available2024-01-20T19:05:21Z-
dc.date.created2021-09-02-
dc.date.issued2010-05-01-
dc.identifier.issn0960-894X-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/131451-
dc.description.abstractWe have synthesized and biologically evaluated 1,4-diazepane derivatives as T-type calcium channel blockers. In this study, we discovered compound 4s, a potential T-type calcium channel blocker with good selectivity over hERG and N-type calcium channels. In addition, it exhibited favorable pharmacokinetic characteristics for further investigation of T-type calcium channel related diseases. (C) 2010 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherPergamon Press Ltd.-
dc.subjectCA2+ CHANNELS-
dc.subjectDESIGN-
dc.subjectANTAGONISTS-
dc.subjectMIBEFRADIL-
dc.subjectDISCOVERY-
dc.titleSynthesis and biological evaluation of 1,4-diazepane derivatives as T-type calcium channel blockers-
dc.typeArticle-
dc.identifier.doi10.1016/j.bmcl.2010.03.084-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBioorganic & Medicinal Chemistry Letters, v.20, no.9, pp.2705 - 2708-
dc.citation.titleBioorganic & Medicinal Chemistry Letters-
dc.citation.volume20-
dc.citation.number9-
dc.citation.startPage2705-
dc.citation.endPage2708-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000276816600001-
dc.identifier.scopusid2-s2.0-77950943791-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusCA2+ CHANNELS-
dc.subject.keywordPlusDESIGN-
dc.subject.keywordPlusANTAGONISTS-
dc.subject.keywordPlusMIBEFRADIL-
dc.subject.keywordPlusDISCOVERY-
dc.subject.keywordAuthorT-type calcium channel blockers-
dc.subject.keywordAuthor1,4-Diazepane-
dc.subject.keywordAuthorPharmacokinetics-
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