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dc.contributor.authorPriyadarshi, Amit-
dc.contributor.authorRoy, Ankoor-
dc.contributor.authorKim, Key Sun-
dc.contributor.authorKim, Eunice EunKyeong-
dc.contributor.authorHwang, Kwang Yeon-
dc.date.accessioned2024-01-20T19:33:07Z-
dc.date.available2024-01-20T19:33:07Z-
dc.date.created2021-09-02-
dc.date.issued2010-04-
dc.identifier.issn0006-291X-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/131591-
dc.description.abstractThis study reports the crystal structures of Bcl-xl wild type and three Bcl-xl mutants (Y101A, F105A, and R139A) with amino acid substitutions in the hydrophobic groove of the Bcl-xl BH3 domain An additional 12 ordered residues were observed in a highly flexible loop between the alpha 1 and alpha 2 helices, and were recognized as an important deamidation site for the regulation of apoptosis The autophagy-effector protein, Beclin 1, contains a novel BH3 domain (residues 101-125), which binds to the surface cleft of Bcl-xl, as confirmed by nuclear magnetic resonance (NMR) spectroscopy and analytical gel-filtration results Gossypol, a potent inhibitor of Bcl-xl, had a K-d value of 0 9 mu M In addition, the structural and biochemical analysis of five Bcl-xl substitution mutants will provide structural insights into the design and development of anti-cancer drugs (C) 2010 Elsevier Inc All rights reserved-
dc.languageEnglish-
dc.publisherAcademic Press-
dc.titleStructural insights into mouse anti-apoptotic Bcl-xl reveal affinity for Beclin 1 and gossypol-
dc.typeArticle-
dc.identifier.doi10.1016/j.bbrc.2010.03.002-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBiochemical and Biophysical Research Communications, v.394, no.3, pp.515 - 521-
dc.citation.titleBiochemical and Biophysical Research Communications-
dc.citation.volume394-
dc.citation.number3-
dc.citation.startPage515-
dc.citation.endPage521-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000276785900015-
dc.identifier.scopusid2-s2.0-77950518734-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryBiophysics-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaBiophysics-
dc.type.docTypeArticle-
dc.subject.keywordPlusCRYSTAL-STRUCTURE-
dc.subject.keywordPlusPEPTIDE COMPLEX-
dc.subject.keywordPlusREGULATORS-
dc.subject.keywordPlusBCL-X(L)-
dc.subject.keywordPlusRAY-
dc.subject.keywordAuthorBcl-xl-
dc.subject.keywordAuthorBeclin-
dc.subject.keywordAuthorApoptosis-
dc.subject.keywordAuthorGossypol-
dc.subject.keywordAuthorMutation-
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