Full metadata record

DC Field Value Language
dc.contributor.authorChoi, Ki Young-
dc.contributor.authorChung, Hyunjin-
dc.contributor.authorMin, Kyung Hyun-
dc.contributor.authorYoon, Hong Yeol-
dc.contributor.authorKim, Kwangmeyung-
dc.contributor.authorPark, Jae Hyung-
dc.contributor.authorKwon, Ick Chan-
dc.contributor.authorJeong, Seo Young-
dc.date.accessioned2024-01-20T20:03:35Z-
dc.date.available2024-01-20T20:03:35Z-
dc.date.created2021-09-02-
dc.date.issued2010-01-
dc.identifier.issn0142-9612-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/131858-
dc.description.abstractHyaluronic acid nanoparticles (HA-NPs), which are formed by the self-assembly of hydrophobically modified HA derivatives, were prepared to investigate their physicochemical characteristics and fates in tumor-bearing mice after systemic administration. The particle sizes of HA-NPs were controlled in the range of 237-424 nm by varying the degree of substitution of the hydrophobic moiety. When SCC7 cancer cells over-expressing CD44 (the receptor for HA) were treated with fluorescently labeled Cy5.5-HA-NPs, strong fluorescence signals were observed in the cytosol of these cells, suggesting efficient intracellular uptake of HA-NPs by receptor-mediated endocytosis. In contrast, no significant fluorescence signals were observed when Cy5.5-labeled HA-NPs were incubated with normal fibroblast cells (CV-1) or with excess free-HA treated SCC7 cells. Following systemic administration of Cy5.5-labeled HA-NPs with different particle sizes into a tumor-bearing mouse, their biodistribution was monitored as a function of time using a non-invasive near-infrared fluorescence imaging system. Irrespective of the particle size, significant amounts of HA-NPs circulated for two days in the bloodstream and were selectively accumulated into the tumor site. The smaller HA-NPs were able to reach the tumor site more effectively than larger HA-NPs. Interestingly, the concentration of HA-NPs in the tumor site was dramatically reduced when mice were pretreated with an excess of free-HA. These results imply that HA-NPs can accumulate into the tumor site by a combination of passive and active targeting mechanisms. (C) 2009 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherELSEVIER SCI LTD-
dc.subjectGLYCOL CHITOSAN NANOPARTICLES-
dc.subjectRECEPTOR-MEDIATED ENDOCYTOSIS-
dc.subjectIN-VIVO-
dc.subjectCANCER-CHEMOTHERAPY-
dc.subjectANTITUMOR EFFICACY-
dc.subjectDOXORUBICIN-
dc.subjectDELIVERY-
dc.subjectCELLS-
dc.subjectTHERAPEUTICS-
dc.subjectPACLITAXEL-
dc.titleSelf-assembled hyaluronic acid nanoparticles for active tumor targeting-
dc.typeArticle-
dc.identifier.doi10.1016/j.biomaterials.2009.09.030-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBIOMATERIALS, v.31, no.1, pp.106 - 114-
dc.citation.titleBIOMATERIALS-
dc.citation.volume31-
dc.citation.number1-
dc.citation.startPage106-
dc.citation.endPage114-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000272364600013-
dc.identifier.scopusid2-s2.0-70350335729-
dc.relation.journalWebOfScienceCategoryEngineering, Biomedical-
dc.relation.journalWebOfScienceCategoryMaterials Science, Biomaterials-
dc.relation.journalResearchAreaEngineering-
dc.relation.journalResearchAreaMaterials Science-
dc.type.docTypeArticle-
dc.subject.keywordPlusGLYCOL CHITOSAN NANOPARTICLES-
dc.subject.keywordPlusRECEPTOR-MEDIATED ENDOCYTOSIS-
dc.subject.keywordPlusIN-VIVO-
dc.subject.keywordPlusCANCER-CHEMOTHERAPY-
dc.subject.keywordPlusANTITUMOR EFFICACY-
dc.subject.keywordPlusDOXORUBICIN-
dc.subject.keywordPlusDELIVERY-
dc.subject.keywordPlusCELLS-
dc.subject.keywordPlusTHERAPEUTICS-
dc.subject.keywordPlusPACLITAXEL-
dc.subject.keywordAuthorHyaluronic acid-
dc.subject.keywordAuthorNanoparticle-
dc.subject.keywordAuthorPassive targeting-
dc.subject.keywordAuthorActive targeting-
dc.subject.keywordAuthorTumor specificity-
Appears in Collections:
KIST Article > 2010
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE