Doxorubicin-polyphosphazene conjugate hydrogels for locally controlled delivery of cancer therapeutics

Authors
Chun, ChangJuLee, Sun M.Kim, Chang W.Hong, Ki-YunKim, Sang Y.Yang, Han K.Song, Soo-Chang
Issue Date
2009-09
Publisher
ELSEVIER SCI LTD
Citation
BIOMATERIALS, v.30, no.27, pp.4752 - 4762
Abstract
Poly(organophosphazene)-doxorubicin (DOX) conjugate bearing hydrophobic L-isoleucine ethyl ester (IleOEt) and hydrophilic alpha-amino-omega-methoxy-poly(ethylene glycol) with molecular weight of 550 Da (AMPEG 550) along with carboxylic acid as a functional group was synthesized to create a drug delivery system, which is based on locally injectable, biodegradable, and thermosensitive hydrogels. In addition to the evaluation of the in vitro and in vivo antitumor activities, the physicochemical properties, hydrolytic degradation, and DOX release profile of the poly(organophosphazene)-DOX conjugate were determined. The aqueous solution of the polymer-DOX conjugate showed a sol-gel transition behavior depending on temperature changes. Based on the in vivo antitumor activities of the locally injected poly(organophosphazene)-DOX conjugate into the tumor-induced nude mice, the conjugate hydrogel after the local injection at the tumor site was shown to inhibit tumor growth more effectively with less toxicity and much longer than doxorubicin and saline as controls, indicating that tumor active DOX from the conjugate hydrogel is released slowly over a longer period of time and effectively accumulated locally in the tumor sites. These results suggest that the poly(organophosphazene)-doxorubicin conjugates hold great potential for use in preclinical and clinical studies as single and/or combination therapies. (C) 2009 Elsevier Ltd. All rights reserved.
Keywords
BIODEGRADABLE THERMOSENSITIVE POLYMERS; AMINO-ACID ESTERS; DRUG-DELIVERY; BOUND DOXORUBICIN; SIDE-GROUPS; ADRIAMYCIN; DAUNORUBICIN; MECHANISMS; RESISTANCE; THERAPY; BIODEGRADABLE THERMOSENSITIVE POLYMERS; AMINO-ACID ESTERS; DRUG-DELIVERY; BOUND DOXORUBICIN; SIDE-GROUPS; ADRIAMYCIN; DAUNORUBICIN; MECHANISMS; RESISTANCE; THERAPY; Localization; Biodegradable; Thermosensitive; Polymer-doxorubicin conjugate; Hydrogel; Antitumor efficacy
ISSN
0142-9612
URI
https://pubs.kist.re.kr/handle/201004/132224
DOI
10.1016/j.biomaterials.2009.05.031
Appears in Collections:
KIST Article > 2009
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE