Full metadata record

DC Field Value Language
dc.contributor.authorBae, H. J.-
dc.contributor.authorSong, J. H.-
dc.contributor.authorNoh, J. H.-
dc.contributor.authorKim, J. K.-
dc.contributor.authorJung, K. H.-
dc.contributor.authorEun, J. W.-
dc.contributor.authorXie, H. J.-
dc.contributor.authorRyu, J. C.-
dc.contributor.authorAhn, Y. M.-
dc.contributor.authorKim, S. Y.-
dc.contributor.authorLee, S. H.-
dc.contributor.authorYoo, N. J.-
dc.contributor.authorLee, J. Y.-
dc.contributor.authorPark, W. S.-
dc.contributor.authorNam, S. W.-
dc.date.accessioned2024-01-20T21:02:50Z-
dc.date.available2024-01-20T21:02:50Z-
dc.date.created2021-09-03-
dc.date.issued2009-08-
dc.identifier.issn0028-2685-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/132288-
dc.description.abstractEphA3 is a component of the Eph/ephrin tyrosine kinase system, which participates in vasculature development. This receptor/ligand system is associated with various signaling pathways related to cell growth and viability, cytoskeletal organization, cell migration, and anti-apoptosis. Accumulated evidence suggests that aberrant regulation of EphA3 and its genetic alterations are implicated in the development and progression of various cancers. However, despite a high incidence of EphA3 over-expression, no such investigation has been performed in hepatocellular carcinoma. Thus, we investigated genetic alterations of the EphA3 gene in 73 cases of hepatocellular carcinoma by single-strand conformational polymorphism and sequencing. One novel D219V missense mutation was found in the extracellular domain of EphA3, and two genetic alterations in the intracellular sterile-a-motif (SAM) domain of EphA3 appeared to be polymorphisms. Although the functional assessments of this mutant are incomplete, it is believed that this novel EphA3 mutation may contribute to the development of hepatocellular carcinoma.-
dc.languageEnglish-
dc.publisherAEPRESS SRO-
dc.subjectSOMATIC MUTATIONS-
dc.subjectCANCER-
dc.subjectCELLS-
dc.subjectEXPRESSION-
dc.subjectGENOMICS-
dc.subjectMELANOMA-
dc.subjectSCREEN-
dc.subjectFAMILY-
dc.titleLow frequency mutation of the Ephrin receptor A3 gene in hepatocellular carcinoma-
dc.typeArticle-
dc.identifier.doi10.4149/neo_2009_04_331-
dc.description.journalClass1-
dc.identifier.bibliographicCitationNEOPLASMA, v.56, no.4, pp.331 - 334-
dc.citation.titleNEOPLASMA-
dc.citation.volume56-
dc.citation.number4-
dc.citation.startPage331-
dc.citation.endPage334-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000271991100008-
dc.identifier.scopusid2-s2.0-68149142724-
dc.relation.journalWebOfScienceCategoryOncology-
dc.relation.journalResearchAreaOncology-
dc.type.docTypeArticle-
dc.subject.keywordPlusSOMATIC MUTATIONS-
dc.subject.keywordPlusCANCER-
dc.subject.keywordPlusCELLS-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordPlusGENOMICS-
dc.subject.keywordPlusMELANOMA-
dc.subject.keywordPlusSCREEN-
dc.subject.keywordPlusFAMILY-
dc.subject.keywordAuthorEph receptor-
dc.subject.keywordAuthorEphA3-
dc.subject.keywordAuthorhepatocellular carcinoma-
dc.subject.keywordAuthormutation-
Appears in Collections:
KIST Article > 2009
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE