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dc.contributor.authorNam, Bong Soo-
dc.contributor.authorKim, Hwan-
dc.contributor.authorOh, Chang-Hyun-
dc.contributor.authorLee, So Ha-
dc.contributor.authorCho, Seung Joo-
dc.contributor.authorSim, Tae Bo-
dc.contributor.authorHah, Jung-Mi-
dc.contributor.authorKim, Dong Jin-
dc.contributor.authorChoi, Jung Hoon-
dc.contributor.authorYoo, Kyung Ho-
dc.date.accessioned2024-01-20T21:03:49Z-
dc.date.available2024-01-20T21:03:49Z-
dc.date.created2021-09-03-
dc.date.issued2009-07-01-
dc.identifier.issn0960-894X-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/132325-
dc.description.abstractThe synthesis of a novel series of aminoquinoline derivatives 1a-p and their antiproliferative activities against A375 human melanoma cell line were described. Most compounds showed superior antiproliferative activities to Sorafenib as a reference compound. Among them, quinolinyloxymethylphenyl compounds 1k and 1l exhibited potent activities (IC50 = 0.77 and 0.79 mu M, respectively) and excellent selectivity against melanoma and fibroblast cell lines. (C) 2009 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherPergamon Press Ltd.-
dc.subjectRANDOMIZED PHASE-III-
dc.subjectMETASTATIC MELANOMA-
dc.subjectDACARBAZINE-
dc.subjectCHEMOTHERAPY-
dc.subjectCISPLATIN-
dc.subjectINTERLEUKIN-2-
dc.subjectEXPERIENCE-
dc.titleAminoquinoline derivatives with antiproliferative activity against melanoma cell line-
dc.typeArticle-
dc.identifier.doi10.1016/j.bmcl.2009.05.007-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBioorganic & Medicinal Chemistry Letters, v.19, no.13, pp.3517 - 3520-
dc.citation.titleBioorganic & Medicinal Chemistry Letters-
dc.citation.volume19-
dc.citation.number13-
dc.citation.startPage3517-
dc.citation.endPage3520-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000266822800035-
dc.identifier.scopusid2-s2.0-66349104493-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusRANDOMIZED PHASE-III-
dc.subject.keywordPlusMETASTATIC MELANOMA-
dc.subject.keywordPlusDACARBAZINE-
dc.subject.keywordPlusCHEMOTHERAPY-
dc.subject.keywordPlusCISPLATIN-
dc.subject.keywordPlusINTERLEUKIN-2-
dc.subject.keywordPlusEXPERIENCE-
dc.subject.keywordAuthorAminoquinolines-
dc.subject.keywordAuthorAntiproliferative activity-
dc.subject.keywordAuthorMelanoma cell line-
dc.subject.keywordAuthorFibroblast cell line-
dc.subject.keywordAuthorSelectivity-
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