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dc.contributor.authorShin, Hong-Sub-
dc.contributor.authorPark, Kwideok-
dc.contributor.authorKim, Ji Heung-
dc.contributor.authorKim, Jae-Jin-
dc.contributor.authorHan, Dong Keun-
dc.contributor.authorMoon, Myoung-Woon-
dc.contributor.authorLee, Kwang-Ryeol-
dc.contributor.authorShin, Ji Hoon-
dc.date.accessioned2024-01-20T21:04:31Z-
dc.date.available2024-01-20T21:04:31Z-
dc.date.created2021-09-03-
dc.date.issued2009-07-
dc.identifier.issn0883-9115-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/132354-
dc.description.abstractThe surfaces of Nitinol (TiNi), a popular metal alloy for arterial stents were thin-coated with diamond-like carbon (DLC) and then grafted with poly(ethylene glycol) (PEG) to increase biocompatibility. The TiNi control, DLC-coated TiNi (TiNi-DLC), and the PEG-grafted TiNi-DLC (TiNi-DLC-PEG) surface characteristics and biocompatibility were evaluated. The hydrophilicity of the TiNi-DLC-PEG significantly increased and the amount of both oxygen and nitrogen on the TiNi-DLC-PEG also increased compared to the TiNi control and TiNi-DLC due to the grafted PEG. The ratio between albumin and fibrinogen was higher on the PEG-grafted surface than the other surfaces when tested with human blood components; the platelet adhesion decreased the most on the TiNi-DLC-PEG surface, indicating improved blood compatibility. For in vivo tests using a rat model, the samples that were implanted for 6 weeks formed fibrous tissue; the tissue layer was much thinner on the PEG-grafted sample than the other two groups. The present results indicate that PEG-grafted TiNi-DLC surface may be effective in enhancing biocompatibility of blood-contacting biomaterials including vascular stents.-
dc.languageEnglish-
dc.publisherSAGE PUBLICATIONS LTD-
dc.subjectENHANCED BLOOD COMPATIBILITY-
dc.subjectSELF-ASSEMBLED MONOLAYERS-
dc.subjectSTAINLESS-STEEL STENTS-
dc.subjectNEGATIVE CILIA CONCEPT-
dc.subjectPOLY(ETHYLENE GLYCOL)-
dc.subjectPROTEIN ADSORPTION-
dc.subjectBIOMEDICAL APPLICATIONS-
dc.subjectIN-VIVO-
dc.subjectSURFACE-
dc.subjectPLASMA-
dc.titleBiocompatible PEG Grafting on DLC-coated Nitinol Alloy for Vascular Stents-
dc.typeArticle-
dc.identifier.doi10.1177/0883911509104273-
dc.description.journalClass1-
dc.identifier.bibliographicCitationJOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS, v.24, no.4, pp.316 - 328-
dc.citation.titleJOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS-
dc.citation.volume24-
dc.citation.number4-
dc.citation.startPage316-
dc.citation.endPage328-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000267602900002-
dc.identifier.scopusid2-s2.0-68149125591-
dc.relation.journalWebOfScienceCategoryBiotechnology & Applied Microbiology-
dc.relation.journalWebOfScienceCategoryMaterials Science, Biomaterials-
dc.relation.journalWebOfScienceCategoryPolymer Science-
dc.relation.journalResearchAreaBiotechnology & Applied Microbiology-
dc.relation.journalResearchAreaMaterials Science-
dc.relation.journalResearchAreaPolymer Science-
dc.type.docTypeArticle-
dc.subject.keywordPlusENHANCED BLOOD COMPATIBILITY-
dc.subject.keywordPlusSELF-ASSEMBLED MONOLAYERS-
dc.subject.keywordPlusSTAINLESS-STEEL STENTS-
dc.subject.keywordPlusNEGATIVE CILIA CONCEPT-
dc.subject.keywordPlusPOLY(ETHYLENE GLYCOL)-
dc.subject.keywordPlusPROTEIN ADSORPTION-
dc.subject.keywordPlusBIOMEDICAL APPLICATIONS-
dc.subject.keywordPlusIN-VIVO-
dc.subject.keywordPlusSURFACE-
dc.subject.keywordPlusPLASMA-
dc.subject.keywordAuthorstent-
dc.subject.keywordAuthornitinol (TiNi alloy)-
dc.subject.keywordAuthorsurface modification-
dc.subject.keywordAuthordiamond-like carbon (DLC)-
dc.subject.keywordAuthorpoly(ethylene glycol) (PEG)-
dc.subject.keywordAuthorbiocompatibility-
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KIST Article > 2009
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