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dc.contributor.authorChae, Choong-Sik-
dc.contributor.authorPark, Jin-Soo-
dc.contributor.authorChung, Soon-Chun-
dc.contributor.authorKim, Tae-Im-
dc.contributor.authorLee, So-Hyoung-
dc.contributor.authorYoon, Kyung-Mi-
dc.contributor.authorShin, Jongheon-
dc.contributor.authorOh, Ki-Bong-
dc.date.accessioned2024-01-20T21:35:20Z-
dc.date.available2024-01-20T21:35:20Z-
dc.date.created2021-09-03-
dc.date.issued2009-03-15-
dc.identifier.issn0960-894X-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/132651-
dc.description.abstractTwo ink genes, inkO and inkD, responsible for the earliest steps of K252a biosynthetic pathway, from Nonomurea longicantena JCM 11136 were heterologously coexpressed in Streptomyces albus J1074. The resultant strain accumulated compound that was purified by HPLC and studied by NMR. Coexpression of inkOD yielded chromopyrrolic acid, the key intermediate in an indolocarbazole biosynthesis. (C) 2009 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherPergamon Press Ltd.-
dc.subjectBIOSYNTHETIC GENE-CLUSTER-
dc.subjectLECHEVALIERIA-AEROCOLONIGENES ATCC-39243-
dc.subjectINDOLOCARBAZOLE COMPOUNDS-
dc.subjectANTICANCER AGENTS-
dc.subjectREBECCAMYCIN-
dc.subjectGENERATION-
dc.subjectDERIVATIVES-
dc.titleProduction of chromopyrrolic acid by coexpression of inkOD in a heterologous host Streptomyces albus-
dc.typeArticle-
dc.identifier.doi10.1016/j.bmcl.2009.02.026-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBioorganic & Medicinal Chemistry Letters, v.19, no.6, pp.1581 - 1583-
dc.citation.titleBioorganic & Medicinal Chemistry Letters-
dc.citation.volume19-
dc.citation.number6-
dc.citation.startPage1581-
dc.citation.endPage1583-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000263933800006-
dc.identifier.scopusid2-s2.0-61349158124-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusBIOSYNTHETIC GENE-CLUSTER-
dc.subject.keywordPlusLECHEVALIERIA-AEROCOLONIGENES ATCC-39243-
dc.subject.keywordPlusINDOLOCARBAZOLE COMPOUNDS-
dc.subject.keywordPlusANTICANCER AGENTS-
dc.subject.keywordPlusREBECCAMYCIN-
dc.subject.keywordPlusGENERATION-
dc.subject.keywordPlusDERIVATIVES-
dc.subject.keywordAuthorK252a-
dc.subject.keywordAuthorHeterologous expression-
dc.subject.keywordAuthorChromopyrrolic acid-
dc.subject.keywordAuthorStreptomyces albus J1074-
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