DSpace at KISTKIST Article2009

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dc.contributor.authorKim, Mi Kyoung-
dc.contributor.authorPark, Kwang-su-
dc.contributor.authorYeo, Woon-Seok-
dc.contributor.authorChoo, Hyunah-
dc.contributor.authorChong, Youhoon-
dc.date.accessioned2024-01-20T22:01:37Z-
dc.date.available2024-01-20T22:01:37Z-
dc.date.created2021-09-03-
dc.date.issued2009-02-01-
dc.identifier.issn0968-0896-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/132751-
dc.description.abstractIn order to discover a quercetin prodrug with improved bioavailability, we synthesized nine quercetin amion acid conjugates and estimated their pharmacokinetic properties including water solubility, stability against chemical or enzymatic hydrolysis, and cell permeability. Among the synthesized quercetin prodrugs, quercetin-glutamic acid conjugate Qu-E (4g/5g) showed remarkable increases in water solubility, stability, and cell permeability compared with quercetin, which warrants further development as a quercetin prodrug. (c) 2008 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.subjectTANDEM MASS-SPECTROMETRY-
dc.subjectINTESTINAL OLIGOPEPTIDE TRANSPORTER-
dc.subjectLIQUID-CHROMATOGRAPHY-
dc.subjectMODEL PRODRUGS-
dc.subjectTRANSEPITHELIAL TRANSPORT-
dc.subjectFLAVONOL METABOLITES-
dc.subjectDIETARY FLAVONOIDS-
dc.subjectBETA-GLUCURONIDASE-
dc.subjectHUMAN PLASMA-
dc.subjectIDENTIFICATION-
dc.titleIn vitro solubility, stability and permeability of novel quercetin-amino acid conjugates-
dc.typeArticle-
dc.identifier.doi10.1016/j.bmc.2008.12.043-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBIOORGANIC & MEDICINAL CHEMISTRY, v.17, no.3, pp.1164 - 1171-
dc.citation.titleBIOORGANIC & MEDICINAL CHEMISTRY-
dc.citation.volume17-
dc.citation.number3-
dc.citation.startPage1164-
dc.citation.endPage1171-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000262980500029-
dc.identifier.scopusid2-s2.0-58949103807-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusTANDEM MASS-SPECTROMETRY-
dc.subject.keywordPlusINTESTINAL OLIGOPEPTIDE TRANSPORTER-
dc.subject.keywordPlusLIQUID-CHROMATOGRAPHY-
dc.subject.keywordPlusMODEL PRODRUGS-
dc.subject.keywordPlusTRANSEPITHELIAL TRANSPORT-
dc.subject.keywordPlusFLAVONOL METABOLITES-
dc.subject.keywordPlusDIETARY FLAVONOIDS-
dc.subject.keywordPlusBETA-GLUCURONIDASE-
dc.subject.keywordPlusHUMAN PLASMA-
dc.subject.keywordPlusIDENTIFICATION-
dc.subject.keywordAuthorQuercetin-
dc.subject.keywordAuthorProdrug-
dc.subject.keywordAuthorSolubility-
dc.subject.keywordAuthorStability-
dc.subject.keywordAuthorPermeability-
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