DSpace at KISTKIST Article2009

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dc.contributor.authorCho, Sungsik-
dc.contributor.authorOh, Sangtae-
dc.contributor.authorUm, Yumi-
dc.contributor.authorJung, Ji-Hee-
dc.contributor.authorHam, Jungyeob-
dc.contributor.authorShin, Woon-Seob-
dc.contributor.authorLee, Seokjoon-
dc.date.accessioned2024-01-20T22:02:55Z-
dc.date.available2024-01-20T22:02:55Z-
dc.date.created2021-09-03-
dc.date.issued2009-01-15-
dc.identifier.issn0960-894X-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/132803-
dc.description.abstractMost of the 10-substituted triazolylartemisinin synthesized via the Huisgen 1,3-dipolar cylcoaddition of diastereomeric 10-azidoartemisinin (5, 6, and 7) with various alkynes (a-h) exhibit strong growth inhibition activity, even at sub-micromolar concentrations, against various cancer cell lines such as DLD-1, U-87, Hela, SiHa, A172, and B16. In particular, 10b and 10f showed a highly strong cytotoxicity. (C) 2008 Published by Elsevier Ltd.-
dc.languageEnglish-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.subjectSOLUBLE DIHYDROARTEMISININ DERIVATIVES-
dc.subjectANTIMALARIAL ACTIVITY-
dc.subjectDIFLUOROMETHYLENE KETONES-
dc.subjectCLICK CHEMISTRY-
dc.subjectDRUG-
dc.subjectGROWTH-
dc.subjectCYCLOADDITION-
dc.subjectINHIBITION-
dc.subjectARTEETHER-
dc.subjectTOXICITY-
dc.titleSynthesis of 10-substituted triazolyl artemisinins possessing anticancer activity via Huisgen 1,3-dipolar cylcoaddition-
dc.typeArticle-
dc.identifier.doi10.1016/j.bmcl.2008.11.067-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.19, no.2, pp.382 - 385-
dc.citation.titleBIOORGANIC & MEDICINAL CHEMISTRY LETTERS-
dc.citation.volume19-
dc.citation.number2-
dc.citation.startPage382-
dc.citation.endPage385-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000261908900020-
dc.identifier.scopusid2-s2.0-57849113145-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusSOLUBLE DIHYDROARTEMISININ DERIVATIVES-
dc.subject.keywordPlusANTIMALARIAL ACTIVITY-
dc.subject.keywordPlusDIFLUOROMETHYLENE KETONES-
dc.subject.keywordPlusCLICK CHEMISTRY-
dc.subject.keywordPlusDRUG-
dc.subject.keywordPlusGROWTH-
dc.subject.keywordPlusCYCLOADDITION-
dc.subject.keywordPlusINHIBITION-
dc.subject.keywordPlusARTEETHER-
dc.subject.keywordPlusTOXICITY-
dc.subject.keywordAuthorArtemisinin-
dc.subject.keywordAuthorTriazolyl artemisinin-
dc.subject.keywordAuthorHuisgen 1,3-dipolar cylcoaddition-
dc.subject.keywordAuthorAnticancer-
dc.subject.keywordAuthorNatural product-
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