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dc.contributor.authorKim, Hye-Jung-
dc.contributor.authorYu, Myeong-Hee-
dc.contributor.authorKim, Hoguen-
dc.contributor.authorByun, Jonghoe-
dc.contributor.authorLee, Cheoju-
dc.date.accessioned2024-01-20T22:32:26Z-
dc.date.available2024-01-20T22:32:26Z-
dc.date.created2021-08-31-
dc.date.issued2008-10-31-
dc.identifier.issn1976-6696-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/133043-
dc.description.abstractColorectal cancer (CRC) is the third most common malignancy in the world. Because CRC develops slowly from removable precancerous lesions, detection of the disease at an early stage during regular health examinations can reduce both the incidence and mortality of the disease. Although sigmoidoscopy offers significant improvements in the detection rate of CRC, its diagnostic value is limited by its high costs and inconvenience. Therefore, there is a compelling need for the identification of noninvasive biomarkers that can enable earlier detection of CRC. Accordingly, many validation studies have been conducted to evaluate genetic, epigenetic or protein markers that can be detected in the stool or in serum. Currently, the fecal-occult blood test is the most widely used method of screening for CRC. However, advances in genomics and proteomics combined with developments in other relevant fields will lead to the discovery of novel non invasive biomarkers whose usefulness will be tested in larger validation studies. Here, noninvasive molecular biomarkers that are currently used in clinical settings and have the potential for use as CRC biomarkers are discussed. [BMB reports 2008; 41(10): 685-692]-
dc.languageEnglish-
dc.publisherKOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY-
dc.subjectFECAL-OCCULT-BLOOD-
dc.subjectABERRANT CRYPT FOCI-
dc.subjectSERUM TUMOR-MARKER-
dc.subjectCOLON-CANCER-
dc.subjectTISSUE INHIBITOR-
dc.subjectK-RAS-
dc.subjectPOTENTIAL MARKER-
dc.subjectDNA METHYLATION-
dc.subjectEUROPEAN GROUP-
dc.subjectP53 MUTATIONS-
dc.titleNoninvasive molecular biomarkers for the detection of colorectal cancer-
dc.typeArticle-
dc.identifier.doi10.5483/BMBRep.2008.41.10.685-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBMB REPORTS, v.41, no.10, pp.685 - 692-
dc.citation.titleBMB REPORTS-
dc.citation.volume41-
dc.citation.number10-
dc.citation.startPage685-
dc.citation.endPage692-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
dc.identifier.kciidART001287517-
dc.identifier.wosid000260569500001-
dc.identifier.scopusid2-s2.0-55249090218-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.type.docTypeReview-
dc.subject.keywordPlusFECAL-OCCULT-BLOOD-
dc.subject.keywordPlusABERRANT CRYPT FOCI-
dc.subject.keywordPlusSERUM TUMOR-MARKER-
dc.subject.keywordPlusCOLON-CANCER-
dc.subject.keywordPlusTISSUE INHIBITOR-
dc.subject.keywordPlusK-RAS-
dc.subject.keywordPlusPOTENTIAL MARKER-
dc.subject.keywordPlusDNA METHYLATION-
dc.subject.keywordPlusEUROPEAN GROUP-
dc.subject.keywordPlusP53 MUTATIONS-
dc.subject.keywordAuthorBiomarker-
dc.subject.keywordAuthorColorectal cancer-
dc.subject.keywordAuthorEarly detection-
dc.subject.keywordAuthorFecal-occult blood test-
dc.subject.keywordAuthorNoninvasive marker-
dc.subject.keywordAuthorProteomics-
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