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dc.contributor.authorByun, Ji Hun-
dc.contributor.authorKim, HyeYun-
dc.contributor.authorKim, YoungSoo-
dc.contributor.authorMook-Jung, Inhee-
dc.contributor.authorKim, Dong Jin-
dc.contributor.authorLee, Won Koo-
dc.contributor.authorYoo, Kyung Ho-
dc.date.accessioned2024-01-20T22:32:37Z-
dc.date.available2024-01-20T22:32:37Z-
dc.date.created2021-09-03-
dc.date.issued2008-10-15-
dc.identifier.issn0960-894X-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/133050-
dc.description.abstractThe synthesis of a novel series of aminostyrylbenzofuran derivatives 1a-w and their inhibitory activities for A beta fibril formation were described. All the synthesized compounds were evaluated by thioflavin T (ThT) assay and displayed potent inhibitory activities for A beta fibril formation. Among them, compounds 1i and 1q exhibited excellent inhibitory activities (IC(50) = 0.07 and 0.08 mu M, respectively) than those of Curcumin (IC(50) = 0.80 mu M) and IMSB (IC(50) = 8.00 mu M) as reference compounds. Both compounds were selected as promising candidates for further biological evaluation. (C) 2008 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.subjectALZHEIMERS-DISEASE-
dc.subjectAMYLOID PLAQUES-
dc.subjectIMAGING AGENTS-
dc.subjectPROTEIN-
dc.subjectPROBES-
dc.subjectBRAIN-
dc.titleAminostyrylbenzofuran derivatives as potent inhibitors for A beta fibril formation-
dc.typeArticle-
dc.identifier.doi10.1016/j.bmcl.2008.08.111-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.18, no.20, pp.5591 - 5593-
dc.citation.titleBIOORGANIC & MEDICINAL CHEMISTRY LETTERS-
dc.citation.volume18-
dc.citation.number20-
dc.citation.startPage5591-
dc.citation.endPage5593-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000259972800056-
dc.identifier.scopusid2-s2.0-53349147027-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusALZHEIMERS-DISEASE-
dc.subject.keywordPlusAMYLOID PLAQUES-
dc.subject.keywordPlusIMAGING AGENTS-
dc.subject.keywordPlusPROTEIN-
dc.subject.keywordPlusPROBES-
dc.subject.keywordPlusBRAIN-
dc.subject.keywordAuthorAlzheimer&apos-
dc.subject.keywordAuthors disease-
dc.subject.keywordAuthorA beta 42 fibrils-
dc.subject.keywordAuthoraminostyrylbenzofurans-
dc.subject.keywordAuthorinhibitory activity-
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