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dc.contributor.authorChoe, Yun Jeong-
dc.contributor.authorSeo, Han Na-
dc.contributor.authorJung, Soo Yeon-
dc.contributor.authorRhim, Hyewhon-
dc.contributor.authorKim, Jungahn-
dc.contributor.authorChoo, Dong Joon-
dc.contributor.authorLee, Jae Yeol-
dc.date.accessioned2024-01-20T22:34:17Z-
dc.date.available2024-01-20T22:34:17Z-
dc.date.created2021-09-03-
dc.date.issued2008-10-
dc.identifier.issn0365-6233-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/133121-
dc.description.abstract3,4-Dihydroquinazoline derivatives have been known to be the novel and potent T-type calcium channel blockers. From a systematic variation of 3,4-dihydroquinazoline derivative 5c (KYS05043), plausible SAR results were established. It was revealed that a 5-(dimethylamino)pentylamino group at R-1, a biphenyl group at R-2, and a benzyl amido group at R-3 in the 3,4-dihydroquinazoline backbone are closely related with the channel selectivity (T/N-type) as well as the potency based on the discovery of Q (KYS05090).-
dc.languageEnglish-
dc.publisherWILEY-V C H VERLAG GMBH-
dc.subjectDERIVATIVES-
dc.subjectALPHA(1G)-
dc.subjectRELEASE-
dc.subjectMUSCLE-
dc.subjectACID-
dc.titleSynthesis and SAR Study of T-Type Calcium Channel Blockers. Part II-
dc.typeArticle-
dc.identifier.doi10.1002/ardp.200800079-
dc.description.journalClass1-
dc.identifier.bibliographicCitationARCHIV DER PHARMAZIE, v.341, no.10, pp.661 - 664-
dc.citation.titleARCHIV DER PHARMAZIE-
dc.citation.volume341-
dc.citation.number10-
dc.citation.startPage661-
dc.citation.endPage664-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000260436300007-
dc.identifier.scopusid2-s2.0-53549106616-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.relation.journalWebOfScienceCategoryPharmacology & Pharmacy-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusDERIVATIVES-
dc.subject.keywordPlusALPHA(1G)-
dc.subject.keywordPlusRELEASE-
dc.subject.keywordPlusMUSCLE-
dc.subject.keywordPlusACID-
dc.subject.keywordAuthorBlockers-
dc.subject.keywordAuthor3,4-Dihydroquinazoline-
dc.subject.keywordAuthorSAR study-
dc.subject.keywordAuthorT-type calcium channel-
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